磁共振心肌灌注检测猪急性心肌梗死的实验研究

目的:探讨磁共振心肌灌注成像技术在检测猪急性心肌梗死后心肌活性中的作用。方法:猪心肌梗死模型13只,均进行快速梯度回波序列(FGREET)首过灌注扫描及反转恢复梯度回波序列(MDE)延迟时相扫描。扫描后处死,分析心肌首过灌注和延迟时相特点,并与病理检查结果进行对照。结果:9只首过灌注时梗死心肌表现为灌注减低,其信号强度显著低于周围心肌,12只延迟期梗死心肌表现为延迟强化,而正常心肌信号强度下降,低于梗死心肌。结论:MR心肌灌注成像可有效检测急性心肌梗死后的梗死心肌。

MR myocardial perfusion imaging in the detecting acute myocardial infarction: an experimental preliminary study in pigs

Objective:To study myocardial first-pass perfusion and delayed-enhancement features in acute myocardial infarction by using fast MRI scanning sequence.Methods:13 pigs myocardial infarctions model,conducted rapid gradient echo sequence(FGREET) first-pass perfusion imaging and inversion recovery gradient-echo sequence(MDE) delayed-enhancement phase scanning.After scanning killed off the first analysis of myocardial perfusion and delayed-phase characteristics,and compared with pathological examination.Results:9 cases(69.2%) over the first reperfusion myocardial infarction showed perfusion defect,signal intensity was significantly lower than the surrounding myocardium,12 cases(92.3%) delayed myocardial infarction showed delayed-enhancement,and normal myocardial signal intensity decrease below myocardial infarction without delay enhance in one cases(7.6%).Conclusion:MR myocardial perfusion imaging can detect acute myocardial infarction non-viable myocardium.