慢性高原病发病机制研究进展

慢性高原病是高原地区危害人体健康的常见慢性病。是长期生活在海拔2500m以上并对缺氧不完全适应的表现,其发病机制普遍认为与高原低氧所引起的高原习服失衡、呼吸驱动减弱、炎性因素,血红蛋白与氧气亲和力下降、促红细胞生成素的合成与释放调节机制紊乱、血清p53和Bcl-xL蛋白的表达等有关系,但其发病机制是多样复杂的,现在尚未阐明。本文对慢性高原病的发病机制研究进展予以综述。

Research Progress about Pathogenesis of Chronic mountain sickness

Chronic mountain sickness is the common chronic disease doing harmful to people＇s health at high altitude, which results from the incompleted accommodation to oxygen-poor of the people who chronically live the place above 2500 altitude. Its pathogenesis is generally considered to be related to many factors, such as high altitude acclimatization imbalance by high altitude hypoxia, reduced respiratory drive, inflammation factors, decreased affinity between hemoglobin and oxygen, disordered regulatory mechanism of the crythropoietin,the expression of serum p53 protein and Bcl-xL protein and so on. Its pathogencsis are complex and diverse, and now has not yet been clarified. This article reviews the research progress about the pathogenesis of chronic mountain sickness.