肥胖蛋白与非胰岛素依赖型糖尿病的关系

目的：探讨肥胖基因的表达产物――肥胖蛋白(OP)与非胰岛素依赖型糖尿病(NIDDM)发生和发展的关系。方法：采用放射免疫分析法测定21例正常人、24例肥胖患者和20例NIDDM患者血浆OP含量。同时测定体质量指数、血浆胆固醇(TC)、甘油三酯(TG)、空腹血糖(BG)、糖化血红蛋白(HbA1)及胰岛素释放试验等指标。结果：NIDDM患者血浆OP含量(81.0±17.5) pg/ml明显低于正常人的血浆OP含量(194.3±17.7) pg/ml。非肥胖的NIDDM患者血浆OP含量(103.5±19.3) pg/ml明显低于非肥胖的正常人血浆OP含量，肥胖的NIDDM患者血浆OP含量(75.3±16.2) pg/ml明显低于肥胖患者的血浆OP含量。结论：OP含量不足是造成肥胖的重要因素之一，OP与NIDDM的发病有密切关系。

The relationship between obese protein and noninsulin-dependent diabetes mellitus

Objective: To explore the role of the obese protein (OP) of the obese gene expressive product in the genesis and development of noninsulin-dependent diabetes mellitus (NIDDM). Methods: Plasma OP levels were measured by radioimmunoassay in 21 cases of normal subjects, 24 adult obese patients and 20 patients with NIDDM. At the same time, the other parameters were measured, including body mass index, plasma cholesterol, triglyceride, fast blood glucose, hemoglobin A1 and the plasma insulin level during glucose tolerance test. Results: The levels of the plasma OP in NIDDM patients (81.0±17.5) pg/ml were very significantly lower than those in normal subjects (194.3±17.7) pg/ml (P<0.01). The levels of the plasma OP in non-obese NIDDM patients were very significantly lower than those in non-obese normal subjects (P<0.01) and the levels of the plasma OP in obese NIDDM patients were very significantly lower than those in obese patients (P<0.01). Conclusion: The plasma OP may be closely related to the genesis of NIDDM. It is one of the important factors resulting in obesity that the plasma levels of OP were lower.