| 注射用脑蛋白水解物的生物活性测定 |
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| 引用本文： | 欧阳杰湖,潘善庆,陈子渊. 注射用脑蛋白水解物的生物活性测定[J]. 中国药事, 2009, 23(2): 125-130 |
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| 作者姓名： | 欧阳杰湖 潘善庆 陈子渊 |
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| 作者单位： | 湖南省药品检验所,长沙,410001 |
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| 摘 要： | 目的采用生物活性测定法加强控制注射用脑蛋白水解物的质量。方法选用18-20g小鼠,雌雄各半,尾静脉注射注射用脑蛋白水解物93.6mg·kg^-1,给药后30min记录小白鼠断头后的呼吸时间和小白鼠常压耐缺氧时间。结果给药组小鼠显著延长断头后的喘气时间（P〈0.05）;给药组小鼠显著延长小鼠常压耐缺氧时间（P〈0.05）。结论该法准确,可靠,可用于注射用脑蛋白水解物的质量控制。
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| 关 键 词： | 生物活性测定 小白鼠断头 小白鼠常压耐缺氧法 喘气时间 注射用脑蛋白水解物 |
The Bioactivity Assay of Cerebroprotein Hydrolysate for Injection |
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| Ouyang Jiehu,Pan Shanqing,Chen Ziyuan. The Bioactivity Assay of Cerebroprotein Hydrolysate for Injection[J]. Chinese Pharmaceutical Affairs, 2009, 23(2): 125-130 |
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| Authors: | Ouyang Jiehu Pan Shanqing Chen Ziyuan |
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| Affiliation: | (Hunan Institute for Drug Control, Changsha 410001) |
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| Abstract: | Objective A bioactivity assay method was established to enhance the qualified control of Cerebroprotein Hydrolysate for Injection. Methods The determination was carried out with qualified mice after 30 minutes administration （dosage, 93.6mg·kg^-1 according to the mice body weight; i.v. vena caudalis）, which was recorded its gasp time after the mice head-breaking and bearing hypoxia at normal pressure. Results The gasp time of the MAT （medication administration team） shoud more notable improvement than that of the CG （control group） （P〈0.05） . Conclusions This method was proved to be simple and reliable, and can be used for the quality control of Cerebroprotein Hydrolysate for Injecyion. |
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| Keywords: | bioactivity assay the mice head-breaking the mice bearing hypoxia at normal pressure Cerebroprotein Hydrolysate for Injection |
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