绝经女性血清瘦素水平与代谢综合征关系

目的 探讨绝经女性血清瘦素与代谢综合征(MS)关系。方法 对沈阳市某社区106名绝经女性进行人体测量、血清瘦素及MS指标测定。结果 因子分析抽出2个公因子,累计方差贡献率为60.7%;核心因子为瘦素-体脂肪,包括瘦素、体脂肪含量、体质指数、腰围;另一因子为MS因子,包括腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇。体脂肪含量和收缩压是预测瘦素的独立变量(R²=0.607,P<0.01);瘦素浓度随MS成分数的增多而升高,MS≥3项组瘦素浓度为(11.33±4.51)ng/mL、2项组为(9.21±4.70)ng/mL,均高于≤1项组的(5.54±3.46)ng/mL(均P<0.05);高瘦素水平组(>9.2 ng/mL)MS的危险度是低瘦素水平组(≤9.2 ng/mL)的4倍(OR=4.00,95% CI=1.34~11.97,P<0.05)。结论 绝经女性瘦素与体脂肪含量、收缩压呈正相关,高瘦素水平可增大MS的危险度。

Relationship between serum leptin and metabolic syndrome in postmenopausal women

Objective To evaluate the relationship between serum leptin and metabolic syndrome(MS) in posmtenopausal women.Methods An thropometry, serum leptin and parameters related to MS were measured among 106 posmt enopausal women in a local community in Shenyang.Results Factor analysis revealed two factors explaining 60.7% of the total variance.The key factors a ssociated with leptin and body fat components included leptin, body fat percentage, body mass index, and waist circum ference; the other factors were characterized by MS components, including waist circum ference, blood pressure, fasting glucose, trigly ceride, and high density lipoprote in cholesterol.Body fat percentage and systolic blood pressure were independent variables for predicting serumleptin(R²=0.607, P<0.01).Serumleptin in the subjects increased with the number of MS components, and leptin levels in the subjects with more than three components(11.33±4.51 ng/m L) and two components(9.21±4.70 ng/mL) were significantly higher than those of with no more than one component(5.54±3.46 ng/mL) (all P<0.05).Risk of MS for the subjects with the high leptin level (> 9.2 ng/mL) was four times higher than those of with loweptin (9.2 ng/mL) (odds ratio=4.00, 95% confidence interval:1.34-11.97; P<0.05).Conclusion Serumleptin positively correlates with body fat percentage and systolic blood pressure and higher leptin level increases the risk of MS in postm enopausal women.