社区老年人血糖水平与MMSE得分关系

目的 探讨不同血糖水平对老年人简单智能量表(minimental state examination,MMSE)得分影响,为预防老年人认知功能下降提供科学依据.方法 于2003年对贵州省贵阳市老年人空腹血糖及MMSE得分进行调查,2008年进行随访;分析基线、随访时不同血糖水平与MMSE得分的关系,以及不同血糖值与随访期间MMSE得分下降的关系.结果 单因素方差分析结果表明,不同性别、年龄、文化程度、血糖不同水平的MMES得分差异有统计学意义;基线时血糖正常者MMSE得分29,空腹血糖受损(IFG)者为28.5,糖尿病者(DM)为28,3组之间差异有统计学意义;随访时血糖正常者MMSE得分27,IFG者为27,糖尿病者(DM)为26,3组之间差异有统计学意义;随访期间不同血糖水平的MMSE得分下降无统计学意义(χ²=2.28,P<0.05);以基线和随访时MMSE得分、MMES得分下降为因变量进行多重线性分析,老年人空腹血糖值有统计学意义.结论 老年人的空腹血糖值异常增高可导致老年人认知功能下降.

Relation between blood glucose and MMSE score among older people in community

Objective To research the effect of different blood glucose level on the score of minimental state exmination(MM SE) among older people and to provide scientific advice for prevention of cognitive decline in the elderly.Methods Baseline information were collected in 2003 among older people in communities of Guiy ang city and the followup was conducted in 2008.The relation between different blood gluco selevel and score of MMSE was analyzed.Results Single factor analysis showed that sex, age, education level were related to MMSE score.At the base line survey, the MMSE score was 29, 28.5, and 28 for people with normal blood glucose, impaired fasting glucose(IFG) and diabetes mitllitus(DM), respectively, with significant difference among the three groups.In the followup survey, the MMSE score was 27,27, and 26 for people with normal blood glucose, IFG, and DM, respectively, with significant differences among the three groups.There was no significant difference in the decrease of MMSE score among the people with different blood glucose during the follow-up(χ²=2.28, P < 0.05).Multifactor analysis showed that there was a significant correlation bewteen fasting glucose and base line MMSE score and the decrease of MMSE score during the followup.Conclusion A bnormal blood glucose could lead to the decline of cognition in older people.