雌鼠妊娠期手机辐射对仔鼠学习记忆影响

目的 研究妊娠期接受手机辐射对仔鼠学习记忆的影响。方法 孕鼠经不同强度手机辐射后,测定新生鼠脑组织乙酰胆碱酯酶(AChE)活力,应用Morris水迷宫测试幼鼠学习记忆能力。结果 与对照组比较,AChE活力升高,其中高、中强度辐射组(0.55±0.20)、(0.51±0.14)U/mgprot与对照组(0.33±0.22)U/mgprot比较,差异有统计学意义(P<0.05);定位航行实验,第2、3d,高、中强度辐射组平均潜伏期分别为(63.9±12.2)、(66.6±20.4)和(55.1±20.5)、(53.3±16.8)s,与对照组(36.2±13.6)、(32.9±16.5)s比较,明显延长,差异有统计学意义(P<0.05),第4 d,各辐射组平均潜伏期均长于对照组,差异有统计学意义(P<0.05);高强度辐射组穿越原平台区次数低于对照组,差异有统计学意义(P<0.05)。结论 妊娠期接受手机辐射对仔鼠学习记忆能力有一定损害。

Effect of electromagnetic radiation of cell phone on learning and memory of offspring rats with maternal exposure

Objective To investigate the effect of maternal cell phone electrom agnetic radiation exposure on learning and memory ability of offspring rats.Methods Pregnant ratswere radiated with cell phone electrom agnetic radiation of different intensity.Then the activity of acetylcholine esterase(AChE) in new born rats' brain tissue was tested and Morris water maze was used to determine the learning and memory ability of the offspring rats.Results Significant increase of AChE activity was detected after the radiation among the rats of high (0.55±0.20 U/mg·prot) and moderate intensity group (0.51±0.14 U/mg·prot) compared to that of the control group(0.33±0.22 U/mg·prot, P<0.05 for all).Significant differences in place navigation were found at the second and third day of the radiation among the high (63.9±12.2, 66.6±20.4s) and moderate intensity group(55.1±20.5, 53.3±16.8s) compared to those of the control group(36.2±13.6, 32.9±16.5s, P<0.05 for all).At the fourth day, significant differences were found in place navigation among the rats of four groups(P<0.05).The offspring rats in high in tensity group showed less times of crossing over the target area than those in control group with a significant difference(P<0.05).Conclusion Exposure to electromagnetic radiation from cell phone during pregnancy has harm effects on learning and memory ability of offspring rats.