| 伐昔洛韦缓释片体外释放速率与人体内吸收速率的相关性 |
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| 引用本文： | 许小红,李铜铃,陈束叶. 伐昔洛韦缓释片体外释放速率与人体内吸收速率的相关性[J]. 中国新药与临床杂志, 2007, 26(10): 759-761 |
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| 作者姓名： | 许小红 李铜铃 陈束叶 |
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| 作者单位： | 1. 成都医学院,药学系,四川,成都,610083
2. 四川大学,华西药学院,四川,成都,610041 |
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| 摘 要： | 目的:研究伐昔洛韦缓释片体外释放速率与人体内吸收速率的相关性。方法:以水为释放介质,测定伐昔洛韦缓释片的体外释放速率;采用Wagner-Nelson法计算单剂量口服缓释片后体内吸收分数,考察吸收相体内吸收与体外释放的相关性。结果:伐昔洛韦缓释片体内吸收分数(f_a)与体外释放速率(f_r)的关系为:f_a=2.11f_r -20.12,r=0.994 0(n=5)。结论:伐昔洛韦缓释片人体内外相关性良好(P<0.001)。
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| 关 键 词： | 伐昔洛韦 片剂 迟效制剂 体内外相关 Wagner-Nelson法 |
| 文章编号： | 1007-7669（2007）10-0759-03 |
| 收稿时间： | 2007-01-26 |
| 修稿时间： | 2007-07-23 |
Correlation between dissolution rate in vitro and absorption rate in vivo of valaciclovir sustained release tablets |
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| XU Xiao-hong,LI Tong-ling,CHEN Su-ye. Correlation between dissolution rate in vitro and absorption rate in vivo of valaciclovir sustained release tablets[J]. Chinese Journal of New Drugs and Clinical Remedies, 2007, 26(10): 759-761 |
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| Authors: | XU Xiao-hong LI Tong-ling CHEN Su-ye |
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| Affiliation: | 1. School of Pharmacy, Chengdu Medical College, Chengdu SICHUAN 610083, China; 2. West China School of Pharmacy, Sichuan University, Chengdu SICHUAN 610041, China |
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| Abstract: | AIM:To explore the in vivo-in vitro correlation of valaciclovir sustained release tablets (VSRT).METHODS:In vitro release rate of VSRT was studied by the Chp basket method using the following conditions:in 900 ml of water at(37.5±0.5)℃at a rotation speed of 100 rpm.In vivo bioavailability was tested in twenty healthy male volunteers and the fractions absorbed were calculated by Wagner-nelson method. RESULTS:The relationship between the release fraction(f_r)and the absorption fraction(f_a)was:f_a=2.11f_r- 20.12,r=0.994 0(n=5).CONCLUSION:There is a good correlationship of VSRT between dissolution rate in vitro and absorption rate in vivo. |
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| Keywords: | valaciclovir tablets delayed-action preparation in vivo-in vitro correlation WagnerNelson method |
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