The effects of histamine on the concentrations of immunoreactive thyrotropin-releasing hormone in the stomach and hypothalamus in rats |
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Authors: | Kouichi Nakada M.D. Terunori Mitsuma Atsushi Furusawa Yoshiaki Maeda Kimitomo Morise |
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Affiliation: | 1. Fourth Department of Internal Medicine, Aichi Medical University, 21 Karimata, Yazako, Nagakute, 480-11, Aichi, Japan 2. First Department of Internal Medicine, Nagoya University School of Medicine, 466, Nagoya, Japan
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Abstract: | The effects of histamine and its related compounds on the concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) in the stomach, gastric juice and hypothalamus in rats were studied. Histamine, ranitidine or ethanolamine was injected intraperitoneally, and the rats were decapitated at various times after the injection. Ir-TRH concentrations in the stomach, gastric juice and hypothalamus were measured by a radioimmunoassay. Ir-TRH concentrations in the stomach decreased significantly after histamine injection and increased significantly after ranitidine injection in a dose-dependent manner, but did not change with ethanolamine. Ir-TRH concentrations in the gastric juice increased in a dose-dependent manner, peaking at 30 min after histamine injection, and its effect was blocked with ranitidine. Ir-TRH concentrations in the hypothalamus elevated significantly after histamine injection and reduced significantly after ranitidine injection, but did not change with ethanolamine. The effects of histamine on ir-TRH concentrations in the stomach and hypothalamus were significantly blocked with ranitidine, but not with ethanol-amine. These findings suggest that histamine stimulates ir-TRH release from the stomach and inhibits ir-TRH release from the hypothalamus, and that these effects of histamine on ir-TRH release are mediated via an H2-receptor. Portions of this work were presented at the 75th annual meeting of Japanese Society of Gastroenterology. March 1989 in Yokohama, Japan. |
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Keywords: | H2-receptor histamine ranitidine thyrotropin-releasing hormone |
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