中老年原发性高血压病和2型糖尿病血瘀证与非血瘀证患者血清瘦素水平的比较

目的:研究中老年人群中原发性高血压和2型糖尿病血瘀证与非血瘀证患者血清瘦素(Leptin)水平的变化及意义。方法:采用放射免疫法测定201例高血压病与166例2型糖尿病患者的Leptin水平,比较血瘀证与非血瘀证患者血清Leptin水平的变化,并观察其与性别、年龄、体重指数(BMI)、脂肪百分比(％Fat)、空腹血糖(FBG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG、内皮素(ET)、血浆胰岛素(INS)等指标的关系。结果:血瘀证与非血瘀证患者年龄、％Fat、HDL-C、ET 4项指标差异有非常显著性意义(P<0.01,P<0.05);多元线性相关结果显示瘦素与ET呈负相关,与BMI、％Fat呈正相关;在逐步回归分析中HDL-C、ET最后进入方程。结论:血瘀证与非血瘀证患者的血清Leptin水平变化不大;ET是与血清Leptin水平变化的主要相关因素。

A Comparison on the Level of Serum Leptin in Middle-Aged and Aged Hypertension and Type 2 Diabetes with Blood-Stasis Syndrome

Ubjective: To study The change and significance of serum leptin (SL) level in middle - aged and aged essential hyper ?tension and type 2 diabetes with blood -stasis syndrome (BSS) and non-blood - stasis syndrome (NBSS) . Methods: The SL level in 201 cases of hypertension and 166 cases of type 2 diabetes mellitus were determined by radioimmunoassay to compare the variation between BSS and NBSS and observe the relationship with sex, age, body weight index (BMI) percentage of fat (% Fat), fasting blood sugar (FBG, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol(LDL - C) triglyc-eride (TG), endothelin (ET) and serum insulin (INS). Results: The age, % Fat, HDL - C and ET were significantly different between BSS and NBSS ( P < 0. 01, P < 0. 05) . The multiple linear correlation showed that SL and ET were in negative correlation, and SL and BMI, % Fat in positive correlation. The slepwise regression analysis showed that HDL - C and ET entered the equation eventually. Conclusion: The difference of SL level between BSS and NBSS is not marked, and ET is the main correlated factor for the change of SI,