高血糖对急性脑梗死病灶、病情及预后的影响

目的:探讨急性脑梗死时高血糖对梗死范围、病情的影响及控制血糖与短期预后的关系.方法:将194例急性脑梗死患者分为正常血糖组、糖尿病高血糖组及梗死后高血糖组,观察各组梗死灶大小、病情轻重分布及控制血糖与短期预后的关系.结果:三组梗死灶大小与病情轻重分布差异有显著性(P＜0.005).正常血糖组梗死灶小、病情轻,糖尿病高血糖组和梗死后高血糖组病情重,后者梗死范围大.梗死后高血糖组血糖控制者病灶缩小较未控制者明显.控制血糖对短期神经功能的恢复无明显影响.结论:高血糖可加重脑缺血性损害,控制血糖有利于梗死灶缩小.

Influence of hyperglycemia on extent of the focus,clinical neurological deficits and prognosis in acute cerebral infarction

Objective:To explore the influence of hyperglycemia on extent of the focus,clinical neurological deficits and the short term prognosis in patients with acute cerebral infarction.Methods:One hundred ninty four patients with acute cerebral infarction were divided into three groups:normal glycemic group,diabetes mellitus hyperglycemic group and hyperglycemia after cerebral infarction group.The distribution of the size of focus and clinical neurological deficit scores in different groups and the relationship between the rectification of blood glucose level and the short term prognosis were studied.Results:There was significant difference in distribution of the size of focus and neurological deficit scores among the three groups( P <0.005).The clinical neurological deficits were more serious in diabetes mellitus hyperglycemic group and hyperglycemia after cerebral infarction group and the focuses of cerebral infarction were larger later.The outback of the focus in patients with rectified blood glucose level was more obvious than that in patients with hyperglycemia in hyperglycemia after cerebral infarction group.Conclusions:The hyperglycemia in cases with acute cerebral infarction exacerbates the damages of the brain and the focus can shrink by rectification of blood glucose level.