| 运用HPLC及液相色谱质谱联用技术分析临床药品事件 |
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| 引用本文： | 周宁,高钧,王洪亮,李琳.运用HPLC及液相色谱质谱联用技术分析临床药品事件[J].中国药物警戒,2014(1):54-56. |
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| 作者姓名： | 周宁 高钧 王洪亮 李琳 |
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| 作者单位： | [1]北京博爱医院药剂科,北京100068 [2]中国医学科学院药物研究所,北京100050 |
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| 摘 要： | 目的采用药学技术分析奥美拉唑变色事件的原因。方法HPLC及液相色谱质谱联用技术定性测定变色药液中的反应物质。结果该变色反应为奥美拉唑与盐酸氨溴索反应所致，氨溴索通过小壶入奥美拉唑通路，并未进入患者体内。结论运用药学技术可以辅助还原药品事件，尽快弄清事件为药品本身质量问题还是操作失误所致。
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| 关 键 词： | HPLC 液相色谱质谱联用技术 药品事件 |
Analysis of Clinical Drug Event by HPLC and HPLC-MS |
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| ZHOU Ning,GAO Jun,. WANG Hong-liang,LI Lin.Analysis of Clinical Drug Event by HPLC and HPLC-MS[J].Chinese JOurnal of Pharmacovigilance,2014(1):54-56. |
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| Authors: | ZHOU Ning GAO Jun WANG Hong-liang LI Lin |
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| Institution: | 1Beijing Bo-ai Hospital, Beijing 100068, China; 2Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050, China) |
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| Abstract: | Objective To analyze the color change event of omeprazole by pharmaceutical technology. Methods The contents of the mixed solution were determined using HPLC and HPLC-MS methods. Results The result showed that omeprazole was mixed with ambroxolhydrochloride, which caused the color change reaction. No mixed solution was infused into the patient. Conclusion HPLC and HPLC-MS are applicable methods in the analysis of drug event. This study might serve as a reference for dealing with events alike. |
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| Keywords: | HPLC HPLC-MS drug event |
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