362例脑梗死患者证候与梗死后抑郁及认知障碍关系的研究

目的观察脑梗死各证候与梗死后抑郁及认知障碍关系。方法比较脑梗死各证候伴发抑郁、认知障碍。以及同时伴发抑郁与认知障碍的例数，并比较各证候间HAMD与MMSE评分之间的差异。结果肝阳暴亢，风火上扰证和阴虚风动证伴发抑郁的例数多于其他3证（P〈0．05），HAMD评分亦高于其余3证（P〈0．05）。气虚血瘀和阴虚风动证伴发抑郁的例数多于其他3证（P〈0．05），MMSE评分亦低于其余3证（P〈0．05）；阴虚风动证同时伴发抑郁与认知障碍的例数，明显高于其他4证（P〈0．05）。结论脑髓空虚是脑梗死后抑郁和认知障碍的发病基础，肝失疏泄是脑梗死后抑郁发病的重要病机。

Relationship Study on Depression and Cognitive Disorder after Infarction in 362 Cases of Cerebral Infarction Patients

Objective： To investigate the relationship of traditional Chinese medicines （TCM） syndrome of cerebral infarction and the depression and cognitive disorder after infarction. Methods： These indicators were comapred such as the number of cases of cerebral infarction TCM syndrome with the depression and cognitive disorder,the number of cases with the depression and cognitive disorder simultaneously. Meanwhile,the difference between different TCM syndromes of HAMD and MMSE scores were compared. Results： The numbers with depression of liver yang hyperactivity, phlegm-wind interferece,wind formation from yin deficiency were significantly higher than the other 3 groups （P〈 0.05）. The HAMD score was higher than the other 3 groups （P〈 0.05）. The numbers with depression of qi deficiency and blood stasis,wind formation from yin deficiency were significantly higher than the other 3 groups （P〈 0.05）. The MMSE score was lower than the other 3 groups （P〈 0.05）. The numbers with depression and cognitive disorder of wind formation from yin deficiency were significantly higher than the other 4 groups （P〈 0.05）. Conclusion： The brains empty is the basis of pathogenesis of depression and cognitive disorder after cerebral infarction. The liver dysfunction is the important mechanism of pathogenesis of depression after cerebral infarction.