心肌酶检测对新生儿病理性黄疸的临床意义

目的：探计新生儿病理性黄疸心肌酶变化及临床意义，方法：分别于入院时（治疗前）和治疗后（显性黄疸消退后），抽不抗凝血2ml，用全自动生化分析仪测定心肌酶、肝功能、肾功能等10项，部分病人同时作心电图检查，结果，新生儿病理性黄疸40例心肌酶均升高，其中4种酶升高者24例（60％），3种酶升高者16例（40％），新生儿生理性黄疸30例，心肌酶1种或2种升高者5例，两组比较差异异有非常显著意义（P＜0．01），病程在7d以上，总胆红素，心肌酶明显高于病程在7d 以上者。治疗前后，总胆红素心肌酶比较，差异有非常显著意义（P＜0．01）。结论：新生儿病理性黄疸可出现心肌损害，与黄疸出现时间和程度有关，在抗菌上，加用VitC,ATP.CoA营养心肌细胞，心肌酶随显性黄疸消退而下降，疗效较好，随访5例病理性黄疸心肌酶未恢复正常者，均在1－2月内心肌酶恢复正常，心肌损害呈可逆性。

The clinic significance of testing mgocardium enxyme to the pathologic jaundice for the newborn

Objective:[WT5BZ][ST5BZ]To investigate the changes and significance of testing myocardium enzyme to the pathologic jaundice for the newborn .[WT5HZ]Methods:[WT5BZ]When the patients go to hospital (before the treatment)and after the tratment,draw 2ml blood without anticoagulant,have a myocardium enzyme test,liver function test,renal function test and so on, and some patients may have electrocardiogram tests.[WT5HZ]Results:[WT5BZ]The myocardium enzyme of 40 patients with pathologic jaundice has risen,of whom 24 with 4 kinds of enzyme rising(60%),16 with 3 kinds enzyme rising(40%).Among 30 patients with the physiologic jaundice,5 patients with 1 or 2 kinds of enzyme rising.Compared with the two groups,the difference is very evident and significant (P<0.01).The total bilirubin and the myocardium enzyme of the patients whose course of disease is within 7 days are higher than those whose course of disease is over 7 days.Compare the total bilirubin and the myocardium enzyme before the treatment and after the treatment,the difference is very evident and significant(P<0.01).[WT5HZ]Conclusion:[WT5BZ]The newborn with the pathologic jaundice may have their cardiac muscle damaged.It is connected with the degree and the time when jaundice appears.After using the antibiotic,add nutrition myocardium cells with VitC.ATP.CoA,the myocardium enzyme will fall with the jaundice disappearing.The curative effect is good.15 patients whose pathologic jaundice and the myocardium enzyme are unusual all recover normally within 1 2 months.The damage of cardiac muscle is reversible. [WT5HZ]