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| 依达拉奉预防脑梗死溶栓后再灌注损伤的临床研究 | |
| 引用本文： | 王广生,王轩,贾丽丽,杨明峰,孙保亮. 依达拉奉预防脑梗死溶栓后再灌注损伤的临床研究[J]. 泰山医学院学报, 2009, 30(11) |
| 作者姓名： | 王广生 王轩 贾丽丽 杨明峰 孙保亮 |
| 作者单位： | 1. 章丘市人民医院神经内科,章丘,250200 2. 章丘市人民医院神经内科,章丘,250200;山东省高校脑微循环重点实验室、泰山医学院附属医院神经内科,泰安,271000 3. 山东省高校脑微循环重点实验室、泰山医学院附属医院神经内科,泰安,271000 |
| 摘 要： | 目的探讨依达拉奉对预防急性脑梗塞溶栓后再灌注损伤的作用。方法急性脑梗塞患者104例,所有病例予尿激酶100万单位静脉溶栓,随机分为溶栓组58例和溶栓+依达拉奉组46例;溶栓组在溶栓后应用尼莫地平、维生素E、C等常规药物,溶栓+依达拉奉组在溶栓后给予依达拉奉30mg,2次/天,连用7天,观察神经功能缺损减轻后又加重的病例数及血清超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondiadehyde,MDA)含量的测定。结果溶栓组有8例溶栓后出现再灌注损伤,发生率14.29%;溶栓+依达拉奉组有1例,发生率2.17%。与溶栓组比较,溶栓+依达拉奉组血清SOD活性显著提高,MDA水平明显下降(P<0.01)。结论依达拉奉能有效预防急性脑梗塞溶栓后再灌注损伤的发生。 |
| 关 键 词： | 急性脑梗塞 溶栓 再灌注损伤 依达拉奉 |
The clinical research for edaravone in preventing ischemia-reperfusion injury after cerebral infarction |
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| WANG Guang-sheng,WANG Xuan,JIA Li-li,YANG Ming-feng,SUN Bao-liang. The clinical research for edaravone in preventing ischemia-reperfusion injury after cerebral infarction[J]. Journal of Taishan Medical College, 2009, 30(11) | |
| Authors: | WANG Guang-sheng WANG Xuan JIA Li-li YANG Ming-feng SUN Bao-liang |
| Affiliation: | WANG Guang-sheng; WANG Xuan; JIA Li-li; YANG Ming-feng; SUN Bao-liang (1.Zhangqiu City People's Hospital of Neurology; Zhangqiu 250200; China; 2.Colleges and Universities in Shandong Province Key Laboratory of Cerebral Microcirculation Department of Neurology; Affiliated Hospital of Taishan Medical College Taian; Taian 271000; China); |
| Abstract: | Objective: Discussion of edaravone on the prevention of acute cerebral infarction reperfusion injury after thrombolysis.Methods: 104 patients with acute cerebral infarction were surveyed,All cases were given 1 million units of urokinase for intravenous thrombolysising.And then were randomly divided into groups of 58 cases thrombolytic and thrombolytic plus edaravone group of 46 cases;Thrombolytic group after thrombolytic therapy nimodipine,vitamin E,C and other conventional drugs were used,while thrombolyti... |
| Keywords: | acute cerbral infarction thrombolysis reperfusion injury edaravone |
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