Influence of some immune factors on the IL-6 and soluble IL-2 receptors in haemodialysed patients |
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Authors: | M Kozioł-Montewka A Ksiażek M Majdan D Spasiewicz L Brydak L Janicka S Toś-Luty J Sitkowska C Skórska J Latoszyńska E Przylepa |
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Institution: | (1) Department of Nephrology, University School of Medicine, Institute of Rural Medicine, Lublin, Poland;(2) Department of Virology, National Institute of Higiene, Warsaw, Poland |
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Abstract: | In respect to the immune deficiency state of long-term haemodialysed patients, both cytokines and their receptor disturbances
have been taken into consideration. The purpose of our study was to evaluate the effect of uraemic and haemodialysis factors
on the interleukin-6 and interleukin-2 soluble receptor levels and the reactivity after influenza vaccination. We have found
that IL-6 and IL-2 receptor levels were statistically significantly elevated (98.8±39 pg/ml and 1557±544 U/ml, respectively)
in serum of haemodialysed patients.
The fact that increased immune complexes statistically correlated with soluble IL-2 receptor levels (p<0.01) was very interesting
for us. In order to study the immunological response after vaccination, 10 patients have been investigated after influenza
vaccination. Plasma samples were collected before, as well as 1 and 4 weeks after vaccine administration. Antibody titres
measured by haemagglutinin inhibition showed decreased antibody levels in haemodialysed patients. We conclude that the interleukin
disturbance and the elevated interleukin-2 receptor levels together with the presence of circulating immune complexes can
influence in some way the immune response of haemodialysed patients. |
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