胺碘酮转复心房纤颤时对QT离散度影响

目的 :评价胺碘酮在治疗心房纤颤中对心肌复极的影响。方法 :测量了 4 8例用胺碘酮转复和维持治疗房颤患者的QT间期与QT离散度 ,并与 2 1例阵发房颤和 4 3例健康对照组比较。结果 :阵发房颤动组与健康对照组QT间期和QT离散度无差异 (QT :4 0 5± 4 4vs3 97 3 0ms .QTc :4 48± 4 7vs4 2 4± 2 6ms ,QTD 2 9± 1 7vs2 7± 1 6ms ,QTcD :2 8±1 9vs2 6± 1 8ms ,P >0 .0 5) ,但与前两对照组比 ,胺碘酮明显延长QT期间并使QTD增大 (QT :4 65± 53vs4 0 5± 4 4or3 97± 3 0ms ,QTc :4 49± 54vs4 48± 4 7or 4 2 4± 2 6ms ,QTD :4 7± 2 0vs2 9± 1 9or 2 7± 1 6ms ,QTcD :4 9± 2 1vs2 8± 1 9or 2 6± 1 8ms ,P <0 .0 1 )。结论 :胺碘酮不仅延长心肌复极 ,且使复极离散。

The effects of amiodarone on QT dispersion in patients with atrial fibrillation

OBJECTIVEThis study evaluated the eff ects of amiodarone on the myocardial repolarization in the patients with atrial fibrillation.METHODSQT dispersions measured from 12-lead standard surface ECG were retrospectively assessed in 48 patients treated with Amiodarone ,and compared with that of paroxysmal atrial fibrillation and health groups.RESULTSNo disparity in QT interval and QT dispersion was found between paroxysmal atrial fibrillation and health group(QT405±44vs397+30ms.QTc448±47 vs424±26ms,QTD 29±17vs27±16ms,QTcD28±19vs26±18ms,P>0.05). However,compared with these two group,we found that both of the QT interval and QT dispersion significantly increased in Amiodarone group(QT465±53vs405±44 or 397±30ms,QTc449±54vs448±47 or 424±26ms,QTD47±20vs29±19 or 27±16ms,QTcD 49±21vs28±19 or 26±18ms,P<0.01).CONCLUSIONAmiodaro ne not only effectively control atrial fibrillation with QT interval prolongatio n but also increased QT dispersion.