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Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies — Novel tool for diagnostics and patient follow-up

Authors:	Liv T Osnes Britt Nakken Edit Bodolay Peter Szodoray

Institution:	1. Institute of Immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway;2. Division of Clinical Immunology, Institute of Internal Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Abstract:	Serum and intracytoplasmic cytokines are mandatory in host defense against microbes, but also play a pivotal role in the pathogenesis of autoimmune diseases by initiating and perpetuating various cellular and humoral autoimmune processes.

Keywords:	AIRE autoimmune regulator ApoA1 Alipoprotein A1 Breg regulatory B cell CFS chronic fatigue syndrome CVID common variable immunodeficiency ECP extracorporeal photochemotherapy EPO erythropoietin G-CSF granulocyte colony-stimulating factor HGF hepatocyte growth factor IFN interferon IL interleukin IL-1Ra interleukin-1 receptor alpha IPEX immunodysregulation polyendocrinopathy enteropathy X-linked syndrome iTreg induced regulatory T cell MCTD mixed connective tissue disease ME myalgic encephalitis NK natural killer cell NKT natural killer T cell nTreg natural regulatory T cell PID Primary immunodeficiency PM/DM polymyositis/dermatomyositis RA rheumatoid arthritis RAG recombination activating genes SCID severe combined immunodeficiency SLE systemic lupus erythematosus SNHL sensorineural hearing loss SS Sjö gren's syndrome SSc systemic sclerosis Tc T-cytotoxic cell Th T-helper cell TNF Tumor necrosis factor Treg regulatory T cell TPO thrombopoietin UCTD undifferentiated connective tissue disease U1RNP U1 ribonucleoprotein
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