131I与抗甲状腺药物治疗甲亢性心脏病临床疗效比较

目的: 比较131I与抗甲状腺药物（ATD）治疗甲亢性心脏病的临床疗效。方法: 对226例甲亢性心脏病患者分别采用131I（151例）及ATD（75例）治疗，比较两组病例的临床疗效、治疗前后甲状腺激素水平、心电图及超声心动图变化情况。结果: 131I组的总有效率显著高于ATD组（P<0.01)；且心功能改善及心电图好转率均显著高于ATD组（均P<0.01)。超声心动图检查:131I组患者LVEF、LVEDD、LVESD、SV及CO治疗后较治疗前显著改善(P<0.01)；ATD组治疗前后差异无统计学意义；治疗后两组指标相比差异有统计学意义（P<0.01)。两组治疗后甲状腺激素水平较治疗前均显著降低（P<0.01)，但两组治疗后甲状腺激素水平相比无统计学意义。131I组甲状腺功能减退（甲减）发生率显著高于ATD组（17% vs. 0%,P<0.01）。结论: 131I治疗甲亢性心脏病综合疗效优于ATD，缺点是甲减发生率高。

Efficacy comparison between ~(131)I and anti-thyroid drugs for treatment of thyrotoxic cardiopathy

AIM: To compare the efficacy between 131I and anti-thyroid drugs(ATD) for treatment of thyrotoxic cardiopathy.METHODS: Two hundred and twenty-six patients with thyrotoxic cardiopathy were treated,respectively,with 131I(151 cases) and ATD(75 cases).Efficacy,changes of thyroid hormones,and results of electrocardiogram and echocardiogram were compared between groups.RESULTS: The total effective rate of 131I group was higher than the ATD group(P<0.01) and the improvement of cardiac function and electrocardiogra...