| 自身抗体联合检测在狼疮性肾炎诊断中的价值 |
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| 引用本文： | 查芳芳,朱迎春,周福健. 自身抗体联合检测在狼疮性肾炎诊断中的价值[J]. 西部医学, 2011, 23(2): 258-259. DOI: 10.3969/j.issn.1672-3511.2011.02.021 |
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| 作者姓名： | 查芳芳 朱迎春 周福健 |
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| 作者单位： | 上海复旦大学附属中山医院青浦分院肾内科,上海,201700 |
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| 摘 要： | 目的探讨抗双链DNA抗体（抗dsDNA）、抗脂蛋白酶抗体（抗LPL）和抗C1q抗体（抗C1q）单项检测和联合检测在狼疮性肾炎（LN）诊断中的价值。方法将77例SLE患者分为A组（LN组,38例）和B组（非LN组,35例）,比较抗dsDNA、抗LPL和抗C1q单项及联合检测与LN的关系。结果在A组患者中抗dsDNA、抗LPL、抗C1q单项和联合检测阳性率均显著高于B组（P〈0.05）。3种自身抗体联合检测与单项检测比较,敏感性有所降低,但特异性明显提高。结论抗dsDNA、抗LPL和抗C1q联合检测能很好的帮助早期诊断LN。
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| 关 键 词： | 狼疮性肾炎 抗脂蛋白酶抗体 抗双链DNA抗体 抗C1q抗体 |
The value of self-antibodies on diagnosis of lupus nephritis |
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| ZHA Fang-fang,ZHU Ying-chun,ZHOU Fu-jian. The value of self-antibodies on diagnosis of lupus nephritis[J]. , 2011, 23(2): 258-259. DOI: 10.3969/j.issn.1672-3511.2011.02.021 |
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| Authors: | ZHA Fang-fang ZHU Ying-chun ZHOU Fu-jian |
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| Affiliation: | ZHA Fang-fang,ZHU Ying-chun,ZHOU Fu-jian(Department of Urology,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai 201700,China) |
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| Abstract: | Objective To assess the value of single or combined detection of anti-LPL,anti-dsDNA and anti-C1q antibodies on the diagnosis of lupus nephritis(LN).Methods 73 patients with SLE were divided into group A(LN group,N=38) and group B(non-LN group,N=35).The correlations were compared between single or combined detection of three antibodies(anti-LPL,anti-dsDNA and antiC1q) and lupus nephritis.Results The positive rate of single or combined detection of three antibodies in group A was higher than that in group B(... |
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| Keywords: | Lupus nephritis Anti-LPL antibody Anti-dsDNA antibody Anti-C1q antibody |
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