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| 短期应用糖皮质激素对老年男性慢性阻塞性肺疾病急性加重期患者骨代谢的影响 | |
| 引用本文： | 黄妮雯,刘春涛,任旭斌,孙家杨. 短期应用糖皮质激素对老年男性慢性阻塞性肺疾病急性加重期患者骨代谢的影响[J]. 西部医学, 2011, 23(1): 24-27. DOI: 10.3969/j.issn.1672-3511.2011.01.010 |
| 作者姓名： | 黄妮雯 刘春涛 任旭斌 孙家杨 |
| 作者单位： | 1. 四川大学华西医院呼吸内科,四川,成都,610041 2. 成都市第一人民医院呼吸内科 3. 四川大学华西医院临床药理研究所 |
| 摘 要： | 目的观察不同给药方式对短期应用糖皮质激素老年男性慢性阻塞性肺疾病急性加重期（AECOPD）患者骨代谢的影响。方法对74例短期应用糖皮质激素老年男性AECOPD患者（其中口服给药36例，静脉给药38例）及40例健康体检老年男性检测其骨代谢指标水平并测定腰椎（L2～L4）、左侧髋部骨密度（bone mineral density，BMD）。结果①AECOPD患者BMD较正常对照组明显降低，短期应用糖皮质激素后无明显差异变化。②短期应用糖皮质激素后，骨吸收指标抗酒石酸盐酸性磷酸酶（TRAP）明显升高（P〈0．05），而骨形成指标均较前降低，其中静脉给药组胰岛素样生长因子－I（IGF-I），降钙素（CT），甲状旁腺素（PTH）较治疗前明显降低（P〈0．05）。结论慢性阻塞性肺疾病（COPD）患者可引起骨密度明显降低，短期静脉使用糖皮质激素较口服使用更易引起骨代谢指标紊乱。 |
| 关 键 词： | 慢性阻塞性肺疾病 骨质疏松 骨密度 糖皮质激素 |
Influence of different delivery methods of glucocorticoid short-term treatment on the bone metabolism in senile male patients with acute exacerbation chronic obstructive pulmonary disease |
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| HUANG NI-wen,LIU CHUN-tao,REN XU-bin,et al. Influence of different delivery methods of glucocorticoid short-term treatment on the bone metabolism in senile male patients with acute exacerbation chronic obstructive pulmonary disease[J]. , 2011, 23(1): 24-27. DOI: 10.3969/j.issn.1672-3511.2011.01.010 | |
| Authors: | HUANG NI-wen LIU CHUN-tao REN XU-bin et al |
| Affiliation: | HUANG NI-wen,LIU CHUN-tao,REN XU-bin,et al(1.Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,2.The First People Hospital of Chengdu,3.Institute of GCP,Chengdu 610041) |
| Abstract: | Objective To observe the influence of different delivery methods of glucocorticoid short-term treatment on the bone metabolism in senile male patients with acute exacerbation chronic obstructive pulmonary disease.Methods 74 senile male patients with AECOPD were delivered glucocorticoid in short-term(36 administrated orally,38 administrated intravenously) and 40 healthy senile men.The biochemical bone markers and the bone mineral density(BMD) of L2~L4,Neck,Ward's triangle and troch of femur were examined.Res... |
| Keywords: | Chronic obstructive pulmonary disease Osteoporosis Bone mineral density Glucocorticoid |
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