EphA2和MMP2在胶质瘤组织表达及其相关性

目的]探讨人脑胶质瘤组织中EphA2和MMP2的表达水平及相关性。方法]采用免疫组织化学SP法检测69例胶质瘤组织、10例正常脑组织中EphA2和MMP2蛋白表达情况,分析两者表达水平与胶质瘤临床病理分级之间的关系及两者的相关性。结果]正常脑组织、低级别胶质瘤组织（Ⅰ～Ⅱ级）和高级别胶质瘤组织（Ⅲ～Ⅳ级）中EphA2蛋白表达的阳性率分别为10.0%（1/10）、37.0%（10/27）、90.5%（38/42）,差异有统计学意义（χ2=33.0826,P=0.000）;正常脑组织、低级别胶质瘤组织和高级别胶质瘤组织中MMP2蛋白表达的阳性率分别为0、14.8%（4/27）、69.0%（29/42）,差异有统计学意义（χ2=28.0869,P=0.000）。在胶质瘤组织中,EphA2与MMP2蛋白表达呈正相关（r=0.660,P=0.000）。结论]EphA2与MMP2同时高表达于胶质瘤组织中,EphA2可能通过影响MMP2而促进肿瘤的侵袭与转移。

Expression of EphA2 and MMP2 and Their Correlation in Glioma

Purpose] To investigate the expression of EphA2 and MMP2 and their correlation in glioma.Methods] The expression of EphA2 and MMP2 in tissue samples of 69 cases with glioma and 10 cases of normal brain tissue was detected by immunohistochemical SP method.The expression level of EphA2 and MMP2,the correlation of them,and their relationship with pathological grade were analyzed.Results] The positive rates of EphA2 protein in normal brain tissues,low-grade glioma(Ⅰ-Ⅱ) and high-grade glioma(Ⅲ-Ⅳ) tissues were 10.0%(1/10),37.0%(10/27) and 90.5%(38/42) respectively,with significant difference(χ2=33.0826,P=0.000).The positive rates of MMP2 protein in normal brain tissues,low-grade glioma and high-grade glioma tissues were 0,14.8%(4/27) and 69.0%(29/42) respectively,with significant difference(χ2=28.0869,P=0.000).There was a positive correlation of EphA2 and MMP2 expression in glioma(r=0.660,P=0.000).Conclusions] EphA2 and MMP2 are both overexpression in glioma.EphA2 may enhance the invasion and metastasis of gliomas through effect on MMP2.