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| 犬血浆中右旋布洛芬和左西替利嗪的正负离子切换LC-MS/MS法测定 | |
| 引用本文： | 钮小英,熊晓云,张逸凡,苏建英,钟大放. 犬血浆中右旋布洛芬和左西替利嗪的正负离子切换LC-MS/MS法测定[J]. 中国医药工业杂志, 2012, 43(4): 286-291 |
| 作者姓名： | 钮小英 熊晓云 张逸凡 苏建英 钟大放 |
| 作者单位： | 1. 苏州大学,江苏苏州215123;中国科学院上海药物研究所,上海201203 2. 西安利君制药有限责任公司,陕西西安,710077 3. 中国科学院上海药物研究所,上海,201203 |
| 摘 要： | 建立了液相色谱-串联质谱法同时测定Beagle犬血浆中的右旋布洛芬和左西替利嗪.使用C18色谱柱,以乙腈-甲醇-5mmol/L乙酸铵溶液(25∶56.25∶18.75)为流动相,采用电喷雾电离源、多反应监测模式,正负离子切换扫描,右旋布洛芬和左西替利嗪在0.2～100μg/ml和0.008～4μg/ml范围内线性关系良好,日内和日间RSD小于8.7％,提取回收率大于80.9％. |
| 关 键 词： | 左西替利嗪 右旋布洛芬 液相色谱-串联质谱 测定 |
Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization |
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| NIU Xiaoying , XIONG Xiaoyun , ZHANG Yifan , SU Jianying , ZHONG Dafang. Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization[J]. , 2012, 43(4): 286-291 | |
| Authors: | NIU Xiaoying XIONG Xiaoyun ZHANG Yifan SU Jianying ZHONG Dafang |
| Affiliation: | 1,2*(1.Soochow University,Suzhou 215123;2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203; 3.Xi’an Lijun Pharmaceutical Co.,Ltd.,Xi’an 710077) |
| Abstract: | A LC-MS/MS method was established for the determination of dexibuprofen and levocetirizine in Beagle dog plasma.A C18 column was used with the mobile phase of acetonitrile-methano1-5 mmol/L ammonium acetate solution(25︰56.25︰18.75).A tandem mass spectrometric detection was conducted using multiple reaction monitoring(MRM) under the positive/negative ionization switching mode.The calibration curves of dexibuprofen and levocetirizine were linear in the ranges of 0.2-100 μg/ml and 0.008-4 μg/ml.The intra-and inter-day RSDs were less than 8.7% and the extraction recoveries were over 80.9%. |
| Keywords: | dexibuprofen levocetirizine LC-MS/MS determination |
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