泮托拉唑预防老年人急性脑血管病并发应激性溃疡出血的临床观察

目的:观察泮托拉唑预防急性脑血管病并发应激性溃疡出血的效果。方法:将207例老年急性脑血管病患者随机分为5组,在常规治疗基础上,治疗组A～D分别给予①泮托拉唑40 mg静滴,qd,②泮托拉唑40 mg静滴,bid,③奥美拉唑40mg静滴,qd,④奥美拉唑40 mg静滴,bid。疗程均为10 d。结果:治疗组A～D的出血率及死亡率分别与对照组相比,差异有显著性(P<0.05),而治疗组A、B、C、D之间两两相比,差异没有显著性(P>0.05)。结论:泮托拉唑可用来预防老年人急性脑血管病并发应激性溃疡出血,并降低死亡率。

Clinical observation on pantoprazole used for the prevention of stress ulcer bleeding of acute cerebro-vascular disease in the aged peoples

OBJECTIVE To observe the clinical effect of pantoprazole in preventing stress ulcer bleeding(SUB) of acute cerebro-vascular disease(ACVD).METHODS 207 elder patients with ACVD were divided randomly into 5 groups(the treatment A-D and the conerol group).Based on routine treatment,group A,group B,group C and group D were given 40mg pantoprazole qd,40mg pantoprazole bid,40 mg omeprazole qd and 40 mg omeprazole bid respectively by intravenous dripping for 10 days.RESULTS Significant difference(P<0.05) of the bleeding rate and the death rate were both found between treatment group of A～D and control group respectively,but no significant difference(P>0.05) were found between either two of treatment group A～D.CONCLUSION Pantoprazole is an effective drug for the prevention SUB of ACVD and loss the death rate of the aged patients.