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泮托拉唑预防老年人急性脑血管病并发应激性溃疡出血的临床观察
引用本文:谭婉燕,熊枝繁.泮托拉唑预防老年人急性脑血管病并发应激性溃疡出血的临床观察[J].中国医院药学杂志,2012(5):356-358.
作者姓名:谭婉燕  熊枝繁
作者单位:华中科技大学同济医学院附属梨园医院消化科
摘    要:目的:观察泮托拉唑预防急性脑血管病并发应激性溃疡出血的效果。方法:将207例老年急性脑血管病患者随机分为5组,在常规治疗基础上,治疗组A~D分别给予①泮托拉唑40 mg静滴,qd,②泮托拉唑40 mg静滴,bid,③奥美拉唑40mg静滴,qd,④奥美拉唑40 mg静滴,bid。疗程均为10 d。结果:治疗组A~D的出血率及死亡率分别与对照组相比,差异有显著性(P<0.05),而治疗组A、B、C、D之间两两相比,差异没有显著性(P>0.05)。结论:泮托拉唑可用来预防老年人急性脑血管病并发应激性溃疡出血,并降低死亡率。

关 键 词:急性脑血管病  应激性溃疡  出血

Clinical observation on pantoprazole used for the prevention of stress ulcer bleeding of acute cerebro-vascular disease in the aged peoples
TAN Wan-yan,XIONG Zhi-fan.Clinical observation on pantoprazole used for the prevention of stress ulcer bleeding of acute cerebro-vascular disease in the aged peoples[J].Chinese Journal of Hospital Pharmacy,2012(5):356-358.
Authors:TAN Wan-yan  XIONG Zhi-fan
Institution:(Division of Gastroenterology,Liyuan Hospital,Tongji Medical College of Huazhong University of Science & Technology,Hubei Wuhan 430077,China)
Abstract:OBJECTIVE To observe the clinical effect of pantoprazole in preventing stress ulcer bleeding(SUB) of acute cerebro-vascular disease(ACVD).METHODS 207 elder patients with ACVD were divided randomly into 5 groups(the treatment A-D and the conerol group).Based on routine treatment,group A,group B,group C and group D were given 40mg pantoprazole qd,40mg pantoprazole bid,40 mg omeprazole qd and 40 mg omeprazole bid respectively by intravenous dripping for 10 days.RESULTS Significant difference(P<0.05) of the bleeding rate and the death rate were both found between treatment group of A~D and control group respectively,but no significant difference(P>0.05) were found between either two of treatment group A~D.CONCLUSION Pantoprazole is an effective drug for the prevention SUB of ACVD and loss the death rate of the aged patients.
Keywords:acute cerebro-vascular disease  stress ulcer  bleeding
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