预防性皮肤护理减轻西妥昔单抗所致痤疮样皮疹

目的研究预防性皮肤护理能否减轻西妥昔单抗所致皮疹。方法我科2009年1月-2010年12月收治的应用西妥昔单抗的96例晚期肿瘤患者随机分为2组,对照组给予常规护理,干预组给予预防性皮肤护理,比较两组皮疹严重程度。结果干预组较对照组皮疹程度轻（Ⅲ级毒性6.67%vs 22.22%,P〈0.05）、发生时间晚（（16.09±5.04）d vs（10.13±2.97）d,P〈0.05）,差异有统计学意义;但发生率（76.67%vs 83.33%,P〉0.05）、持续时间（（34.35±3.19）d vs（36.47±4.52）d,P〉0.05）差异无统计学意义。结论预防性皮肤护理可减轻西妥昔单抗所致皮疹。

Preventive skin nursing relieves cetuximab-induced acne-like rashes

Objective To study whether preventive skin nursing can relieve cetuximab-induced acne rashes.Methods Ninety-six patients with advanced cancer who were treated with cetuximab in our department from January 2009 to December 2010 were randomly divided into control group and intervention group.Patients in control group received general nursing while those in intervention group received preventive skin nursing.Severity of rashes was compared between the two groups.Results The severity of rashes was lower in intervention group than in control group（stage Ⅲ toxicity：6.67% vs 22.22%,P〈0.05） and the occurrence time of rashes was later in intervention group than in control group（（16.09±5.04） days vs（10.13±2.97） days,P〈0.05）.However,no significant difference was observed in the incidence and persistent time of rashes between the two groups（（76.67% vs 83.33%,（34.35± 3.19） days vs（36.47±4.52） days,P〈0.05）.Conclusion Preventive skin nursing can relieve cetuximab-induced rashes.