＋Gz暴露对高胆固醇兔胆囊收缩素、生长抑素及胆道压力和胆汁流量的影响

目的观察＋Gz暴露对高胆固醇饮食兔胆囊收缩素（CCK）、生长抑素（SS）含量及胆道压力和胆汁流量的影响。方法 30只兔随机分为高胆固醇饮食组（对照组）15只（每个时间组5只）,高胆固醇饮食加＋Gz暴露2周组、4周组、6周组（＋Gz暴露组,每组5只）,分别留取各组第2、4、6周实验结束时兔胆囊壁组织,测定CCK、SS的变化,并测取胆道压力及胆汁流量。结果 1）＋Gz暴露组兔CCK含量均低于对照组,且随着＋Gz暴露时间增加CCK含量逐渐降低（F=85.845,P〈0.01）;SS含量均高于对照组,且随着＋Gz暴露时间增加,SS含量逐渐升高（F=71.081,P〈0.01）。2）＋Gz暴露组胆道压力均高于对照组,随暴露时间增加而逐渐升高（P〈0.05）。＋Gz暴露组胆汁流量均低于对照组,且随暴露时间增加而逐渐减少（F=28.354,P〈0.05）。结论 ＋Gz暴露可使高胆固醇饮食兔胆囊黏膜CCK含量降低和SS含量升高,也可引起胆囊排空功能及胆道流体静压异常,提示＋Gz暴露可能加速胆系结石形成。

Effect of +Gz on cholecystokinin, somatostatin, biliary tract pressure, and bile duct flow in rabbits on high cholesterol diets

Objective To observe the effect of ＋Gz on cholecystokinin（CCK）,somatostatin（SS）,biliary tract pressure,and bile duct flow in rabbits on high cholesterol diets.Methods Thirty male rabbits were randomly divided into 2-,4-and 6-week high cholesterol groups（control groups）,high cholesterol plus 2-,4-and 6-week ＋Gz groups（experimental groups）,5 rabbits in each group.Their CCK,SS,biliary tract pressure,and bile duct flow were measured.Results The CCK level was lower in 3 experimental groups than in 3 control groups（F=85.845,P〈0.01）,which decreased with ＋Gz exposure time,while the SS level was significantly higher in 3 experimental groups than in 3 control groups（F=71.081,P〈0.01）,which increased with the ＋Gz exposure time.The biliary tract pressure was higher in 3 experimental groups than in 3 control groups（P〈0.05）,which decreased with the ＋Gz exposure time.The bile duct flow rate was lower in 3 experimental groups than in 3 control groups（F=28.354,P〈0.05）,which decreased with the ＋Gz exposure time.Conclusion ＋Gz exposure may decrease the CCK level,increase the SS level,lead to abnormal bile cyst empting function and bile duct pressure in rabbits on high cholesterol diets,suggesting that ＋Gz exposure can accelerate the formation of gallstones.