Polymorphism of the angiotensin-converting enzyme gene in patients with cerebral infarction in koreans |
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Authors: | Jae-Young Um Hyun-Ju Kim Tae-Jin Choi Chong-Shick Jin Seung-Taeck Park Kang-Chang Lee Hee-Sub Rhee Kang-Min Lee Young-Mi Lee Hyung-Min Kim Nyeon-Hyoung An Jeong-Joong Kim |
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Institution: | (1) College of Pharmacy, Institute of Wonkwang Medical Science, Republic of Korea;(2) Department of Anatomy, School of Medicine, Institute of Wonkwang Medical Science, Republic of Korea;(3) Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan-city, 570-749 Chonbuk, Republic of Korea;(4) Department of Obstetrics and Gynecology, School of Medicine, Center of Oriental Medicinal Science, Genomic Research Center for Immune Disorder, Wonkwang University, Iksan-city, 570-749 Chonbuk, Republic of Korea;(5) Division of Biological Science, College of Natural Science, Chonbuk National University, 561-756 Chonju, Chonbuk, Republic of Korea |
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Abstract: | The relationship between cerebrovascular disease and an insertion/deletion (I/D) polymorphism in the angiotensin-converting
enzyme (ACE) gene is still being debated. The frequency of the DD genotype of the ACE gene was significantly higher in subjects
with than those without cerebral infarction in Japan. The aim of the present study was to assess the relationship between
ACE gene polymorphism and the development of cerebral infarction in a population from Korea. We examined its possible role
as a risk factor in patients with cerebral infarction. The association between ACE gene polymorphism and cerebral infarction
was examined in 106 patients with cerebral infarction and 498 controls without cerebral infarction. Frequencies of the genotypes
and alleles of the ACE gene were investigated. The ACE genotype was analyzed by the polymerase chain reaction (PCR). The frequency
of D allele was 37.7% in patients and 39.1% in controls (X
2=0.128, p=0.720). The frequencies of the genotypes of the ACE gene were II:39.6%, ID:45.3%, and DD:15.1% in patients, and II:37.1%,
ID:47.6%, and DD:15.3% in controls (X
2=0.127, p=0.721). There was no significant difference in the frequency of the DD genotype of the ACE gene, and we did not find any
association between ACE polymorphism and cerebral infarction. These results indicate that ACE polymorphism is not a risk factor
for the development of cerebral infarction in a Korean population. |
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Keywords: | Cerebral infarction angiotensin-converting enzyme gene genotype polymorphism Koreans |
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