Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats |
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| Authors: | N D Nigro A W Bull M E Boyd |
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| Institution: | 1. Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, Geffen School of Medicine, and Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA;2. Department of Psychiatry and Behavioral Sciences, Geffen School of Medicine, University of California, Los Angeles, USA;3. Department of Psychology, University of California, Los Angeles, USA;4. Department of Neurological Surgery, University of California, San Francisco, USA;1. Department of Neurology, Baylor College of Medicine, Houston, TX, USA;2. Neurology Care Line, Michael E DeBakey VA Medical Center, Houston, TX, USA;3. Department of Statistics, Rice University, Houston, TX, USA;4. Department of Neurology, University of California, Los Angeles, CA, USA;5. Department of Neurobiology, Department of Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, University of California, Los Angeles, CA, USA |
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| Abstract: | The effect of the duration and sequence of inhibition of intestinal tumor formation in rats was studied to determine whether part time inhibition has any value. Four groups of male Sprague-Dawley rats were given 8 weekly s.c. injections of azoxymethane (AOM) 8 mg/rat. Three groups were given the inhibitor, difluoromethylornithine (DFMO) in the drinking water; one for the entire 26 weeks of the study, one for the first 13 weeks only, and one for the last 13 weeks. A control group was not given the inhibitor. While the continuous treatment group developed the least number of tumors per rat (1.5 vs. 5 for controls), still both groups given the inhibitor for just 13 weeks also developed fewer tumors than controls 5 vs. 3.2 (early treatment) and 5 vs. 2.8 (late treatment). These results show that part time inhibition, including its late application, does reduce intestinal tumor formation in rats. |
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