平阳霉素联合32P不同治疗方式对儿童血管瘤的疗效对照

目的探讨联用平阳霉素和’2P治疗儿童血管瘤的临床效果，为临床血管瘤的治疗提供有效的借鉴。方法选择2008年5月～2010年5月到我院接受治疗的82例血管瘤患儿作为临床观察对象。将患儿分为观察组和对照组，其中观察组42例，对照组40例。观察组采取平阳霉素和32P注射联合治疗，对照组采取32P局部注射加敷贴的治疗，比较两种方式对不同年龄、不同血管瘤类型、性别以及病灶数量、不良反应发生率方面的差异。结果观察组治疗对海绵血管瘤和混合血管瘤的疗效比较显著，对照组治疗对毛细血管瘤和鲜红斑痣疗效显著；年龄因素对两种儿童血管瘤治疗办法有显著的影响，年龄越小，采用32P＋敷贴治疗的效果越佳，平阳霉素＋，32P对2岁以上的患儿效果更佳；患儿的性别和病灶数量对两种治疗方法的疗效无显著影响；两组不良反应的总发生率比较差异无统计学意义，两种方法引起的不良反应种类存在显著性差异。结论平阳霉素联合32P的方案是治疗年龄稍大的儿童血管瘤的良好途径，值得临床推广。

Comparative effect on different treatment methods of Bleomycin and 32P in children with hemangiomas

Objective To explore the clinical effect of Bleomycin combined with 32p in the treatment of children with he- mangiomas, and to provide the effective reference for the clinical treatment of hemangiomas. Methods From May 2008 to May 2010 in our hospital, 82 cases of children with hemangiomas were selected as the object of clinical observation. The children were divided into two groups, with 42 cases of the observation group and 40 cases of the control group. The obser- vation group was treated by Bleomycin combined with 32p Injection, the control group was treated by 32p for local injection and external application. The different ages, different types of hemangioma, gender and number of lesions and the inci- dence of adverse reactions of two groups were compared. Results The observation group had a significant curative effect on cavernous hemangioma and mixed hemangioma, the control group had a significant curative effect on capillary hemangioma and port wine stains; the age factor had significant influence for treatment approaches of children with hemangioma in two groups, the younger, the better application therapy＇s effect of 32p local injection and external application, Bleomycin com- bined with 32p has a better effect on children over the age of 2; the gender and number of lesions had no significant effect on the efficacy of two treatment methods; there was no significant difference in the incidence of adverse reactions of two groups, but there was a significant difference in the kinds of adverse reactions of two groups. Conclusion Bleomycin combined with 32p is a good way of treating ehter children with hemangioma, which is worthy of promotion.