携带9号染色体臂间倒位对不孕症患者辅助生殖技术妊娠结局的影响

目的:探讨携带9号染色体臂间倒位的不孕症患者行人类辅助生殖技术(ART)助孕后对妊娠结局的影响。方法:选取2008年1月至2009年12月在本中心完成体外受精-胚胎移植周期的不孕症患者。其中,研究组女方24例染色体G显带为46,XX,inv(9)(p11q13),男方染色体正常,共29个治疗周期。同期在本中心行体外受精-胚胎移植治疗的无染色体异常核型的不孕患者988例为对照组(1 032个治疗周期)。结果:研究组与对照组比较,其受精率、卵裂率、优质胚胎率、种植率、妊娠率、出生缺陷率等各项指标的差异均无统计学意义(P>0.05),但研究组早期流产率显著高于对照组(P<0.05),差异有统计学意义。结论:9号染色体臂间倒位对ART受精过程和早期胚胎发育没有显著影响,但可能引起ART助孕后早期流产率升高。

The Effect of Femeal Chromosome 9 Pericentric Inversion on ART Results

Objective To study the effect of femeal Chromosome 9 pericentric inversion on ART results.Methods The infertile patients coming to our center for ART treatment from January 2008 to December 2009 were recruited in this study.Karyotype in chromosome of peripheral blood was analyzed by routine chromosome method and G-banding technique.The patients were divided into two groups according to the Karyotype: the research Group,29 cycles with 46,XX,inv(9)(p11q13);the control group,1032 cycles with normal karyotype.Results There were no statisticall differences in the fertilization rates,cleavage rates,high quality embryo rates,implantation rates,pregnancy rates and birth defects between the two groups(P>0.05),but the rate of early miscarriage in the research Group was higher(P<0.05).Conclusion Femeal chromosome 9 pericentric inversion has no significant effect on the ART process and early embryo development,but may cause an early miscarriage after ART.