| KLK10作为妇科肿瘤标志物的研究进展 |
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| 引用本文： | 余秋梦,陈军剑,郑碧英. KLK10作为妇科肿瘤标志物的研究进展[J]. 中国医药导报, 2012, 9(36): 51-53 |
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| 作者姓名： | 余秋梦 陈军剑 郑碧英 |
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| 作者单位： | 余秋梦 (广东医学院检验学院临床微生物检验学教研室,广东东莞,523808)； 陈军剑 (广东医学院检验学院临床微生物检验学教研室,广东东莞,523808)； 郑碧英 (广东医学院检验学院临床微生物检验学教研室,广东东莞,523808)； |
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| 基金项目： | 广东医学院留学回国人员科研启动经费(项目编号:B2007002) |
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| 摘 要： | 人组织激肽释放酶10（KLK10）又称正常上皮细胞特异性-1（NES1）基因，在人体许多正常组织中表达，但在某些妇科肿瘤组织中表达失调，是近年来发现的一种新型抑癌基因。目前研究认为KLK10基因沉默主摹是由KLK10外显子-3高甲基化引起，KLK10甲基化与肿瘤发生、发展相关，是一种有前景的肿瘤标志物。研究KLK10表达产物及甲基化程度对妇科肿瘤患者的早期诊断及预后等都有重要意义。
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| 关 键 词： | KLK10 甲基化 hK10 妇科肿瘤标志物 |
Progress of KLK10 as a marker of gynecologic tumors |
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| YU Qiumeng,CHEN Junjian,ZHENG Biying. Progress of KLK10 as a marker of gynecologic tumors[J]. China Medical Herald, 2012, 9(36): 51-53 |
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| Authors: | YU Qiumeng CHEN Junjian ZHENG Biying |
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| Affiliation: | Department of Clinical Microbiology Laboratories,School of Inspection Medicine,Guangdong Medical College,Guangdong Province,Dongguan 523808,China |
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| Abstract: | Human tissue kallikrein 10 （KLK10）, also known as normal epithelial cell specific-1 （NES1） gene, express in a variety of normal human tissues, but differentially express in some gynecologic tumors, is a new tumor suppressor gene dis- covered in recent years. The present study find that the KLK10 gene silencing is mainly caused by the KLK10 exon 3 methylation, and KLKI0 methylation is related with tumor development. Researches about KLK10 expression products and the degree of methylation of gynecologic tumor in patients with early diagnosis and prognosis are of importance. |
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| Keywords: | KLK10 Methylation hK10 Gynecological tumor markers |
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