THE EFFECT OF INDOMETHACIN ON THE PSYCHOMOTOR FUNCTION OF PATIENTS WITH RHEUMATIC DISEASES |
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| Authors: | PULLAR, T. MYALL, O. HAIGH, J. R. M. LOWE, J. R. DIXON, J. S. BIRD, H. A. |
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| Affiliation: | Departments of Medicine and Pharmacology, University of Leeds |
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| Abstract: | We have compared the effect of single and multiple doses ofindomethacin and placebo on objective measurements of psychomotorimpairment in patients. Following a single 50 mg dose (n = 8),indomethacin produced psychomotor disturbance in only thosepatients who had no recent history of NSAID exposure. Aftermultiple doses of indomethacin (25 and 50 mg tid for 5 days),no significant psychomotor impairment was observed. We concludethat other NSAIDs may induce cross-tolerance to the psychomotoreffects of indomethacin. Tachyphylaxis may develop to the psychomotordisturbance caused by indomethacin. KEY WORDS: Tachyphylaxis, Tolerance, NSAID, Central nervous system, Flicker fusion threshold, Choice reaction times |
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