1例儿童无症状预激综合征的循证治疗

目的为1例无症状预激综合征儿童患者循证制定治疗方案。方法针对无症状预激综合征患儿是否需要进行预防性射频消融的问题，以“asymptomatic WPW syndrome”为检索词，全面检索Cochrane图书馆（2007年第3期）、MEDLINE（1981—2007）、OVID ACP Journal Club（1991—2007）、BM JClinical Evidence（1999～2007）以及美国国家指南交换中心（1998～2007），获取并评价相关的系统评价、随机对照试验、临床对照试验证据及治疗指南，并将最佳证据用于临床治疗。结果从MEDLINE检索到2篇随机对照试验，结果表明：高危对照组与消融组相比，心律失常事件发生显著增加，高危对照组中多旁道患者比单旁道患者心律失常事件发生显著增加。据此，我们结合医生经验和家长意愿，针对该例患者电生理检查示右侧显性旁道和左侧隐匿性旁道，进行预防性射频消融治疗。出院至今已12个月，未再出现心血管方面的并发症。结论对高危无症状预激综合征患儿进行预防性射频消融安全、有效。

Evidence-Based Treatment for a Child with Asymptomatic Wolff-Parkinson-White Syndrome

Objective To formulate an evidence-based treatment plan for a child patient with Asymptomatic Wolff-Parkinson-White （WPW） Syndrome. Methods Based on the clinical problems whether the patients with asymptomatic WPW syndrome need prevent catheter ablation or not, we used ＂asymptomatic WPW syndrome＂ as the keywords and searched The Cochrane Library （Issue 3, 2007）, MEDLINE （1981 to 2007）, ACP Journal Club （1991 to 2007）, BMJ Clinical Evidence （1999 to 2007） and NGC （1998 to 2007） for systematic reviews, randomized controlled trials （RCTs）, controlled clinical trials and treatment guidelines. The methodological quality of the included studies was assessed to identify the current best evidence. Results Two RCTs were retrieved in MEDLINE. The results showed arrhythmic events increased significantly in the high-risk control group than those in the ablation group, and in the patients with multi-pathways than those with only one pathway. Based on the current evidence, integrated with clinical expertise and the patients＇ values, the patients underwent electrophysiologic test and the result showed the dominance pathway in the right side and the concealed accessory pathway in the left side. Then prevent catheter ablation was performed, and no cardiovascular complications occurred in the following 12 months, which confirmed that the plan was proved optimal. Conclusion The findings of this study should reassure physicians and parents alike that in the children with the WPW syndrome who are at high risk for arrhythmias, ablation is an appropriate option.