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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
Institution:1. Genetics Division, Department of Medicine, Brigham and Women''s Hospital, Boston, MA 02115, USA;2. Harvard Medical School, Boston, MA 02115, USA;3. Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA;4. Belfer Center for Applied Cancer Science, Boston, MA 02115, USA;5. Experimental Therapeutic Core, Dana-Farber Cancer Institute, Boston, MA 02115, USA;6. Departments of Pathology, Brigham and Women''s Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA;7. Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA;8. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;9. Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Abstract:
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  • Keywords:KRAS  lung cancer  NSCLC  MEK  BET  HOXC10  combination therapy  PRC2  SUZ12  EED
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