血尿酸、血清同型半胱氨酸与冠状动脉病变程度的关系分析

目的探讨血尿酸、血清同型半胱氨酸水平与冠心病患者冠脉病变严重程度的关系。方法回顾性分析2018年11月至2019年11月于我院住院的90例冠心病患者作为试验组,纳入同时期性别、年龄相匹配的冠脉造影正常的患者50例作为对照组。根据SYNTAX评分对冠状动脉严重程度进行评分,根据结果分为低危组(<22分)、中危组(23~32分)及高危组(>33分)。记录患者一般临床资料,抽取清晨空腹血化验UA、Hcy、TC、TG、HDL-C、LDL-C,并行冠脉造影检查,比较分析各组患者血脂、UA、Hcy的差异,并进行相关性分析及Logistic回归分析。结果SYNTAX评分中危组、高危组与对照组相比较,TC、LDL-C、UA、HCy升高,差异有统计学意义(P<0.05);UA与SYNTAX评分呈正相关(r=0.487,P<0.05),Hcy与SYNTAX评分呈正相关(r=0.437,P<0.05);Logstic回归分析发现LDL-C、UA、Hcy是冠心病患者冠状动脉病变程度的独立危险因素(P<0.05)。结论血尿酸、血清同型半胱氨酸水平是冠心病患者冠状动脉病变严重程度的危险因素,且血尿酸、血清同型半胱氨酸水平越高,冠脉病变越严重。

Relationship between serum homocysteine and serum uric acid and severity of coronary artery disease in patients with coronary heart disease

Objective To investigate the relationship between serum uric acid and serum homocysteine levels and the severity of coronary artery disease in patients with coronary heart disease.Methods A retrospective analysis was performed on 90 patients with coronary heart disease who were admitted to our hospital from November 2018 to November 2019 as the experimental group,and 50 patients with normal coronary angiography matched with gender and age at the same time were included as the control group.Coronary artery severity was scored according to the SYNTAX score,and the results were divided into low-risk group(<22points),intermediate-risk group(23~32points),and high-risk group(>33points).Record general clinical data of patients,extract early morning fasting blood tests UA,Hcy,TC,TG,HDL-C,LDL-C,and perform coronary angiography,compare and analyze the differences in blood lipids,UA,and Hcy of patients in each group,and perform correlation Analysis and Logistic Regression Analysis.Results Compared with the control group,the SYNTAX score was higher in the middle-risk group and the high-risk group than in the control group.The differences in TC,LDL-C,UA,and Hcy were statistically significant(P<0.05),Hcy was positively correlated with SYNTAX score(r=0.437,P<0.05);Logstic regression analysis found that LDL-C,UA,and Hcy were independent risk factors for the degree of coronary artery disease in patients with coronary heart disease(P<0.05).Conclusion Serum uric acid and serum homocysteine levels are risk factors for the severity of coronary artery disease in patients with coronary heart disease,and the higher the serum uric acid and serum homocysteine levels,the more severe the coronary artery disease.