Sex Differences in Interleukin-6 Responses Over Time Following Laboratory Pain Testing Among Patients With Knee Osteoarthritis |
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| Affiliation: | 2. Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina;3. Department of Orthopedic Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland;4. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland;5. Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women''s Hospital, Boston, Massachusetts;6. Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland;2. Biopsychology and Cognitive Neuroscience, Faculty of Psychology and Sports Science, Bielefeld University, Bielefeld, Germany;2. Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida;2. National Competence Centre for Complex Symptom Disorders, Clinic of Anesthesia and Intensive Care, St. Olav''s University Hospital, Trondheim, Norway;3. Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway;1. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;2. Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. University of Washington School of Medicine, Department of Psychiatry & Behavioral Sciences, Seattle, Washington;3. Cincinnati Children''s Hospital Medical Center, Department of Anesthesiology, Cincinnati, Ohio;4. Northeastern State University, Department of Psychology, Tahlequah, Oklahoma;5. University of Alabama at Birmingham, Department of Psychology, Birmingham, Alabama;6. University of Oklahoma-Tulsa, Department of Social Work, Tulsa, OK |
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| Abstract: | Epidemiological studies suggest that women are not only at a higher risk for developing knee osteoarthritis (KOA), but also report greater symptom severity compared to men. One potential underlying mechanism of these sex differences may be exaggerated inflammatory responses to pain among women compared to men. The present study examined sex differences in interleukin-6 (IL-6) response over time following experimental pain testing. We hypothesized that women, when compared to men, would show greater IL-6 reactivity when exposed to acute pain in a human laboratory setting. Eighty-four participants (36 men and 48 women) with KOA scheduled for total knee arthroplasty underwent a quantitative sensory testing (QST) battery. A total of seven IL-6 measurements were taken, twice at baseline, once immediately after QST, and every 30 minutes up to 2 hours after QST. Consistent with our hypothesis, women, when compared to men, showed accelerated increases in IL-6 levels following laboratory-evoked pain, even after controlling for body mass index, marital status, clinical pain, evoked pain sensitivity, and situational pain catastrophizing. Given that KOA is a chronic condition, and individuals with KOA frequently experience pain, these sex differences in IL-6 reactivity may contribute to the maintenance and/or exacerbation of KOA symptoms.PerspectivesThe present study demonstrates that women, when compared to men, exhibit greater IL-6 reactivity after exposure to laboratory-evoked pain. Such sex differences may explain the mechanisms underlying women's higher chronic pain risk and pain perception, as well as provide further insight in developing personalized pain interventions. |
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