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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
Affiliation:1. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA;2. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA;4. Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA;5. Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA;6. Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA;7. Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;8. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;9. Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA;10. School of Life Science and Technology, Tongji University, 200092 Shanghai, China;11. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;12. Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA;13. Stem Cell Program, Boston Children''s Hospital, Boston, MA 02215, USA;14. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;15. Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA 02210, USA;16. Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA 02215, USA;17. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;18. Dana-Farber/Boston Children''s Cancer and Blood Disorders Center, Boston, MA 02115, USA;19. Department of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;20. Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, LC4114, Boston, MA 02215, USA;21. Department of Pathology, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA 02215, USA;22. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
Abstract:
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  • Keywords:epidermal growth factor receptor  lung cancer  drug resistance  drug tolerance  dormancy  YAP  senescence
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