Role of the FKBP5 polymorphism rs1360780, age,sex, and type of surgery in weight loss after bariatric surgery: a follow-up study |
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| Institution: | 1. Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain;2. Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain;3. Endocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Medicine Department Universitat Autònoma de Barcelona, Sabadell, Spain;4. Institut d’Investigació i Innovació Parc Taulí, Sabadell, Spain;5. Secció d’Estadística, Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain;6. Mental Health Department, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain;7. Depression and anxiety program, Department of Mental Health, Parc Tauli Sabadell, Hospital Universitari, Barcelona, Spain;8. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain;9. Centre for Biomedical Research Network on Mental Health, Instituto de Salud Carlos III, Barcelona, Spain;1. Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil;2. Departamento de Gastroenterologia, Disciplina de Cirurgia do Aparelho Digestivo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil;3. Departamento de Patologia da Faculdade de Medicina FMUSP e Departamento de Psicologia Experimental do Instituto de Psicologia da Universidade de Sao Paulo, Sao Paulo, Brazil;4. Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil;1. Medical School, University of Michigan, Ann Arbor, Michigan;2. Department of Surgery, University of Michigan, Ann Arbor, Michigan;1. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts;2. Center for Surgery and Public Health, Brigham & Women’s Hospital, Boston, Massachusetts;1. Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;2. Surgery Department, Northumbria NHS Foundation Trust, Newcastle upon Tyne, United Kingdom |
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| Abstract: | BackgroundEmerging evidence suggests that the FK506 binding protein 51 (FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation. The T allele of a functional polymorphism in FKBP5 (rs1360780), has been associated with the expression of FKBP51 and weight loss after bariatric surgery.ObjectiveTo examine the role of the FKBP5 rs1360780 polymorphism in relation to age, sex, and type of surgery in weight loss after bariatric surgery in patients with severe obesity.SettingUniversity Hospital in SpainMethodsA cohort of 151 obese patients submitted to Roux-en-Y gastric bypass (62.3%) and sleeve gastrectomy (37.7%) were followed-up during 24-months (t24m; loss to follow-up: 0%). During the postoperative period body mass index (BMI) and percentage of excess and total weight loss were evaluated.ResultsThe BMI analysis showed an effect of the interaction FKBP5 genotype by sex (P = .0004) and a tendency to the interaction genotype by surgery (P = .048), so that men carrying the T allele had higher BMI at t24m than those without the T allele, and T-allele carriers that underwent sleeve gastrectomy had higher BMI at t24m than the noncarriers. Additionally, we found an interaction between FKBP5 and age for the percentage of excess weight loss and BMI (P = .0005 and P = 1.5e?7, respectively), whereby individuals >48 years with the T allele displayed significant differences for the analyzed variables at t24m compared with the homozygotes for the alternate C allele showing lower weight loss.ConclusionFKBP5 rs1360780 genotype has specific effects on weight loss outcomes after bariatric surgery depending on sex, age, and type of surgery, suggesting worse results in older males carrying the T allele who have undergone sleeve gastrectomy. |
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| Keywords: | Obesity Bariatric surgery Weight loss outcomes BMI Follow-up Sex Age rs1360780 |
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