脓毒症相关性脑病治疗进展

脓毒症相关性脑病(SAE)是脓毒症进程中常见的并发症,并SAE患者病死率较高,远期认知功能障碍显著影响幸存者的生活质量。其发病机制仍未阐明,缺乏特异性治疗方法,目前仍以脓毒症综合救治为主,多种针对脑病的干预措施尚处于研究阶段。未来研究需明确减少脓毒症大脑炎性反应、保护血脑屏障、抑制神经递质传递异常等病理生理损伤关键点的方法,从而防治SAE患者脑功能永久性损害。

Progress in sepsis-associated encephalopathy therapy

Sepsis-associated encephalopathy(SAE)is a common complication of sepsis.Not only the cognitive impairment which may develop in the future can reduce the quality of life,but also there is a high mortality in patients with this complication.There is no clear pathogenesis characterized and no specific therapy developed up to date.The synthetic treatment for sepsis is the most commonly used therapy.However,the treatment for encephalopathy is still under research.Therapy that can reduce inflammation caused by SAE,protect the blood-brain barrier,inhibit neurotransmitter abnormality,and restrain other key pathophysiology injuries should be developed in the future to prevent the permanent brain functional damage caused by SAE in patients.