Multisensorial Perception in Chronic Migraine and the Role of Medication Overuse |
| |
| Institution: | 2. Department of Psychology, Milan Center for Neuroscience - NeuroMi, University of Milano-Bicocca, Milano, Italy;3. Laboratory of Neuropsychology, IRCSS Istituto Auxologico, Milano, Italy;4. Department of Brain and Behavioural Sciences, University of Pavia, Italy;2. Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, Brazil;3. Faculty of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo, São Paulo Brazil;4. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil;2. Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women''s Hospital, Boston, Massachusetts;3. Department of Neurology, Albany Medical College, Albany, New York;4. Department of Orthopedics and Rehabilitation Medicine, University of Wisconsin, Madison, Wisconsin;5. Department of Neurology, University of Minnesota, Minneapolis, Minnesota;2. National Health and Medical Research Council Centre of Research Excellence in Road Traffic Injury Recovery, The University of Queensland, Brisbane, Australia;3. School of Psychology, The University of Queensland, Brisbane, Australia;4. Addiction and Mental Health Services, Metro South Hospital and Health Service, Brisbane, Australia;5. School of Communication, Queensland University of Technology, Brisbane, Australia;11. School of Pharmacy, The University of Queensland, Brisbane, Australia;1. Clinical Health Promotion Centre, Medical Faculty, Lund University, Lund, Sweden;2. Department of Community Health Systems, University of California, San Francisco, United States of America;3. Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden |
| |
| Abstract: | Multisensory processing can be assessed by measuring susceptibility to crossmodal illusions such as the Sound-Induced Flash Illusion (SIFI). When a single flash is accompanied by 2 or more beeps, it is perceived as multiple flashes (fission illusion); conversely, a fusion illusion is experienced when more flashes are matched with a single beep, leading to the perception of a single flash. Such illusory perceptions are associated to crossmodal changes in visual cortical excitability. Indeed, increasing occipital cortical excitability, by means of transcranial electrical currents, disrupts the SIFI (ie, fission illusion). Similarly, a reduced fission illusion was shown in patients with episodic migraine, especially during the attack, in agreement with the pathophysiological model of cortical hyperexcitability of this disease. If episodic migraine patients present with reduced SIFI especially during the attack, we hypothesize that chronic migraine (CM) patients should consistently report less illusory effects than healthy controls; drugs intake could also affect SIFI. On such a basis, we studied the proneness to SIFI in CM patients (n = 63), including 52 patients with Medication Overuse Headache (MOH), compared to 24 healthy controls. All migraine patients showed reduced fission phenomena than controls (P < .0001). Triptan MOH patients (n = 23) presented significantly less fission effects than other CM groups (P = .008). This exploratory study suggests that CM – both with and without medication overuse – is associated to a higher visual cortical responsiveness which causes deficit of multisensorial processing, as assessed by the SIFI.PerspectiveThis observational study shows reduced susceptibility to the SIFI in CM, confirming and extending previous results in episodic migraine. MOH contributes to this phenomenon, especially in case of triptans. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
