Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome |
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| Institution: | 1. Unidad de Cirugía Metabólica, Hospital Universitario Virgen de la Victoria, Málaga, Spain;2. Unidad Gestión Clínica Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain;3. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain;4. Unidad Gestión Clínica Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain;1. Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil;2. Departamento de Gastroenterologia, Disciplina de Cirurgia do Aparelho Digestivo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil;3. Departamento de Patologia da Faculdade de Medicina FMUSP e Departamento de Psicologia Experimental do Instituto de Psicologia da Universidade de Sao Paulo, Sao Paulo, Brazil;4. Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil;1. Department of Surgery, Blacktown Hospital and Mount Druitt Hospitals, Sydney, Australia;2. Blacktown and Mount Druitt Clinical School, Western Sydney University, Blacktown, Australia;1. Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;2. Surgery Department, Northumbria NHS Foundation Trust, Newcastle upon Tyne, United Kingdom |
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| Abstract: | BackgroundRecent works have reported that bariatric surgery has remarkable effects on the metabolome, which might be potentially associated to the metabolic improvement of this procedure in patients with obesity. Serum polyamines, metabolites derived from amino acid metabolism, have been recently related to the metabolic status in obese individuals. However, the impact of bariatric surgery on the circulating levels of polyamines remains elusive.ObjectiveTo evaluate the effect of bariatric surgery on serum polyamine levels and to evaluate the association of changes in these molecules with metabolic improvement in patients with morbid obesity.SettingVirgen de la Victoria University Hospital, Malaga, Spain.MethodsThis study included 32 morbidly obese patients (weight index ≥40 kg/m2) with metabolic syndrome, who underwent sleeve gastrectomy. Serum levels of polyamines (putrescine, spermidine, and spermine), acetylpolyamines, and polyamine-related amino acids (arginine and ornithine) were assessed at baseline and 6 months after bariatric surgery, and were analyzed in an ultraperformance liquid chromatography–mass spectrometry platform.ResultsOur metabolomic analysis revealed a significant rise in several metabolites related to the polyamine metabolism, such as putrescine and acetyl derivatives of spermidine and spermine in serum samples from morbidly obese patients after bariatric surgery. Changes in serum levels of both putrescine and acetylputrescine were associated to the resolution of metabolic syndrome after surgery.ConclusionOur study indicates that bariatric surgery affects the serum polyamine pattern and the resolution of metabolic syndrome after bariatric surgery is associated to specific changes in the serum polyamine metabolome. |
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| Keywords: | Bariatric surgery Obesity Metabolic syndrome Metabolomics Polyamines |
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