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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
Institution:1. Department of Dermatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, Hunan 410008, China;2. Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan 410008, China;3. Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan 410008, China;4. Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan 410008, China;5. Research Center of Molecular Metabolomics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;6. Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China;7. Shanghai Institute of Immunology, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;8. Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030, USA;9. Department of Biostatistics, HuaJia Biomedical Intelligence, ShenZhen 518054, China;10. Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan 410078, China;11. Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;12. Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, Hunan 410082, China;13. Department of Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;14. Department of Dermatologic Surgery Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu 210042, China;15. Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China;16. Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;17. Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;18. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;19. Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan;20. Department of Biotechnology, Asia University, Taichung 413, Taiwan
Abstract:
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