Biomarkers Profile of People With Sarcopenia: A Cross-sectional Analysis From UK Biobank |
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| Affiliation: | 1. Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK;2. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK;3. Centre of Exercise Physiology Research (CIFE), Universidad Mayor, Santiago, Chile;4. Research Group in Education, Physical Activity and Health (GEEAFyS), Universidad Católica del Maule, Talca, Chile;1. CIRO+, Department of Research & Development, Horn, the Netherlands;2. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands;3. Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands;4. Viscovery Software GmbH, Vienna, Austria;5. School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Centre, Maastricht, the Netherlands;6. Ludwig Boltzman Institute for Lung Health, Vienna, Austria;1. Institute of Cardiovascular and Medical Sciences, United Kingdom;2. Institute of Health and Wellbeing, United Kingdom;3. Robertson Centre for Biostatistics, University of Glasgow, United Kingdom;1. Department of Medicine, Geriatrics Section, University of Padova, Italy;2. Department of Neurosciences, University of Padova, Padova, Italy;3. Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy;4. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8 AZ, United Kingdom;5. Health Service and Population Research Department, Institute of Psychiatry, King’s College London, De Crespigny Park, Box SE5 8 AF London, United Kingdom;6. Faculty of Health, Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, United Kingdom;7. National Research Council, Aging Branch, Institute of Neuroscience, Padova, Italy |
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| Abstract: | ObjectiveThis study aimed to characterize the biomarker profile of sarcopenic vs nonsarcopenic men and women, using the current European Working Group on Sarcopenia in Older People (EWGSOP2) definition in the UK Biobank study.DesignCross-sectional study.Setting and ParticipantsA total of 396,707 (68.8% women, age 38 to 73) participants from UK Biobank.MeasuresThirty-three biomarkers, standardized to sex-specific z-scores, were included in the analysis. Associations between these biomarkers and sarcopenia, defined using EWGSOP2 criteria, were examined using multiple linear regression.ResultsHigher concentrations of rheumatoid factor, C-reactive protein, cystatin C, sex hormone-binding globulin, gamma-glutamyltransferase, alkaline phosphatase, and total protein, as well as lower concentrations of insulin-like growth factor-1, albumin, creatinine, sodium, and systolic blood pressure, were associated with sarcopenia in both men and women. However, some of the associations differed by sex. Sarcopenia was associated with higher concentrations of phosphate, lipoprotein A, and lower of diastolic blood pressure, HbA1c, urea, glucose, total bilirubin, and testosterone in women only, and with higher concentrations of high-density lipoprotein, aspartate aminotransferase, and direct bilirubin and lower values of apolipoprotein A, vitamin D, and apolipoprotein B in men only.Conclusions and ImplicationsSeveral biomarkers were associated with sarcopenia in men and women using the new EWGSOP2 statement. However, some of these associations and their magnitude differed between men and women. Considering the EWGSOP2 updated its statement on the definition of sarcopenia in 2019, this study enables us to update the study of the biomarkers profile of people with sarcopenia. |
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| Keywords: | Sarcopenia biomarkers handgrip strength muscle weakness |
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