先天性心脏病患儿血浆NT-proBNP与肺动脉压的关系

目的 探讨先天性心脏病（先心病）患者血浆NT-proBNP与肺动脉压之间的关系。方法 将在先心病门诊就诊筛选出的120例先心病患儿依据彩超检查结果分为对照组（肺动脉压正常组,n=60,PASP〈20 mm Hg）和实验组（肺动脉高压组,n=60）,肺动脉高压组根据彩超检测脉动脉压结果分为A组（PASP 20-30 mm Hg）,B组（PASP 30-50 mm Hg）,C组（PASP〉50 mm Hg）,分别检测患者血浆NT-proBNP水平。结果 对照组血浆NT-proBNP含量明显小于实验组（t=25,P〈0.01）;先心病患者血浆NT-proBNP随着肺动脉压升高而明显升高,差异有统计学意义（组间比较t检验,P〈0.01）。结论 先心病合并肺动脉高压患者血浆NT-proBNP是升高的,NT-proBNP与肺动脉压存在相关性,NT-proBNP可作为先心病肺动脉高压评价的一个客观指标。

Relationship of NT - proBNP serum and pulmonary artery pressure in congenital heart disease

Objective To explore the relationship of NT-proBNP serum and pulmonary artery pressure in congenital heart disease.Methods 120 cases were divided into control group(pulmonary artery pressure <20 mm Hg) and study group(pulmonary artery pressure was beyond normal).Then study group were divided into three groups of A,B and C.PASP of group A 20-30 mm Hg,group B 30-50 mm Hg,group C >50 mm Hg).Results The content of NT-proBNP in study group was higher than in control group(p<0.01).Conclusion NT-proBNP in serum is increasing with pulmonary artery pressure.NT-proBNP may be as a index for assay the indication of operation for congenital heart disease.