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Temporal evolution of Acinetobacter baumannii ST107 clone: conversion of blaOXA-143 into blaOXA-231 coupled with mobilization of ISAba1 upstream occAB1 |
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| Authors: | Fernanda Rodrigues-Costa Rodrigo Cayô Adriana Pereira Matos Raquel Girardello Willames M.B.S. Martins Floristher Elaine Carrara-Marroni Ana Cristina Gales |
| Affiliation: | 1. Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil;2. Laboratório de Microbiologia Clínica, Hospital Universitário de Londrina, Departamento de Patologia Análises Clínicas e Toxicológicas, Universidade Estadual de Londrina - UEL, Londrina - PR, Brazil |
| Abstract: | Nine carbapenem-resistant Acinetobacter baumannii isolates carrying blaOXA-231 and an ISAba1 upstream occAB1 were evaluated. They were clonally related and belonged to ST107. An OXA-143-producing A. baumannii ST107 strain (Ac-148) that did not possess ISAba1 upstream occAB1 was included in the analysis. Reduction in the expression of occAB1 and a 4-fold increase of carbapenem MICs were observed for all isolates, except for the Ac-148 strain, probably due to the presence of ISAba1 upstream occAB1 but in the same transcriptional orientation. We reported an A. baumannii ST107 clone carrying blaOXA-143 that acquired a mutation resulting into blaOXA-231 and mobilized ISAba1 upstream occAB1. |
| Keywords: | Clone evolution Antimicrobial resistance Outer membrane protein β-lactamase Insertion sequence Multidrug-resistant pathogen |
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