妊娠期肝内胆汁淤积症合并乙型肝炎病毒感染对围生儿预后的影响

目的探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy, ICP)合并乙型肝炎病毒（HBV）感染对围生儿预后的影响。方法回顾性分析78例ICP合并HBV感染和62例ICP未合并HBV感染孕妇的围生儿结局，观察两组早产率、剖宫产率、胎儿窘迫率、新生儿窒息率及新生儿体重。结果ICP合并HBV感染组早产率为64.10%（50/78），ICP未合并HBV感染组早产率为38.71%（24/62），两组比较，差异有高度显著性（χ2=8.94，P＜0.01）；两组剖宫产率、胎儿窘迫率、新生儿窒息率及新生儿体重差异均无显著性（均P＞0.05）。结论ICP合并HBV感染易引起早产，对此类孕妇应加强孕期监护和治疗，保证围生儿的安全和健康。

Impact of intrahepatic cholestasis of pregnancy with HBV infection on prognosi

Objective To evaluate the impact of intrahepatic cholestasis of pregnancy （ICP） with HBV infection on prognosis of perinatal infants. Methods By retrospective investigation, 78 cases whose mothers with ICP and HBV infection and 62 cases whose mothers with ICP but without HBV infection were compared and analyzed, the weight of perinatal infants, incidence of preterm delivery, cesarean delivery, fetal distress, asphyxia of perinatal infants were analysed. Results The incidence of preterm delivery whose mothers with ICP and HBV infection was 64.10% （50/78）, and whose mothers with ICP but without HBV infection was 38.71% （24/62）, there was significant difference between the two groups（χ^2 = 8.94, P〈0.01 ）, whereas the incidence of cesarean delivery, fetal distress, asphyxia and weight of perinatal infants had no statistical difference（All P〉0.05）. Conclusion ICP with HBV infection can increase the incidence of preterm delivery. Monitoring and treatment should be strengthened for HBV infected pregnant women with ICP, so as to ensure the safety and health of perinatal infants.