老年高血压患者动态血压负荷和脉搏波传导速度的相关性研究 |
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引用本文: | 孙尚文,路方红,赵颖馨,王舒健,刘振东,孙颖.老年高血压患者动态血压负荷和脉搏波传导速度的相关性研究[J].中华老年心脑血管病杂志,2012,14(7). |
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作者姓名: | 孙尚文 路方红 赵颖馨 王舒健 刘振东 孙颖 |
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作者单位: | 山东省医学科学院基础医学研究所心血管病防治研究中心,济南,250062 |
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摘 要: | 目的探讨老年高血压患者24 h动态血压负荷与颈桡动脉脉搏波传导速度(crPWV)的相关性。方法选取60~79岁的老年原发性高血压患者187例,对所有入选对象进行24 h动态血压监测,根据获取的24 h动态血压监测参数分为杓型组90例与非杓型组97例,选择同期体检人群82例为正常对照组。所有受试者行24 h动态血压监测,应用脉搏波速度测定仪测定crPWV,并进行分析。结果杓型组及非杓型组24 h、昼间及夜间收缩压、舒张压负荷均显著高于正常对照组(P<0.01)。非杓型组夜间血压负荷较杓型组升高(P<0.05)。杓型组及非杓型组crPWV均较正常对照组升高(P<0.05)。控制性别、年龄因素后,老年高血压患者24 h收缩压、夜间收缩压负荷、昼间舒张压负荷是crPWV影响的主要因素。结论老年高血压患者动态血压负荷升高,大动脉顺应性降低,其中24 h收缩压、夜间收缩压负荷、昼间舒张压负荷是影响大动脉顺应性的主要危险因素。
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关 键 词: | 高血压 血压测定 血压监测 便携式 脉搏 昼夜节律 危险因素 |
Correlation between ambulatory blood pressure load and pulse wave velocity in elderly hypertensive patients |
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Abstract: | Objective To study the correlation between 24 h ambulatory blood pressure load and carotid -radial pulse wave velocity(crPWV)in elderly hypertensive patients.Methods The 24 h ambulatory blood pressure was monitored in 187 elderly primary hypertensive patients.The patients were divided into dipper group(n = 90) and non-dipper group(n = 97) according to their 24 h ambulatory blood pressure and 82 healthy elderly individuals served as a control group.Their 24 h ambulatory blood pressure and crPWV were measured.Results The 24 h,day and nocturnal SBP and DBP load were significantly higher in dipper group and non-dipper group than in control group(P<0.01).The nocturnal SBP load and the crPWV were significantly higher in non-dipper group than in dipper group(P<0.05).The 24 h and day SBP load and the nocturnal DBP load were the major influencing factors for crPWV after adjustment of sex and age.Conclusion The 24 h SBP load increases while the compliance of conducting arteries decreases in elderly hypertensive patients.The 24 h and nocturnal SBP load and the day DBP load are the major risk factors for the compliance of conducting arteries. |
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Keywords: | hypertension blood pressure determination blood pressure monitoring ambulatory pulse circadian rhythm risk factors |
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