原发性高血压患者血浆肾素活性水平与血压和尿钠的关系 |
| |
引用本文: | 姜娟,孙宁玲,王鸿懿,马庆春,何燕,孔令云. 原发性高血压患者血浆肾素活性水平与血压和尿钠的关系[J]. 中华老年心脑血管病杂志, 2012, 14(8): 810-813 |
| |
作者姓名: | 姜娟 孙宁玲 王鸿懿 马庆春 何燕 孔令云 |
| |
作者单位: | 1. 100044,北京大学人民医院心脏中心高血压研究室 2. 昆明市延安医院干疗科 |
| |
基金项目: | 国家高技术研究863发展计划 |
| |
摘 要: | 目的分析原发性高血压患者血浆肾素活性水平与血压、尿钠排泄的关系。方法原发性高血压患者479例,根据血浆肾素活性水平的5分位排序,分为3组,低肾素组93例,中间肾素组291例,高肾素组95例。各组血浆肾素活性与24 h动态血压及24 h尿钠排泄情况进行相关性分析。结果与低肾素组比较,中间肾素组和高肾素组年龄明显偏低,血浆肾素活性明显增高,差异有统计学意义(P<0.05,P<0.01)。低肾素组老年人、女性、非杓型血压比例明显高于高肾素组,差异有统计学意义(P<0.01)。血浆肾素活性水平与24 h尿钠排泄、24 h血压呈负相关(P<0.05,P<0.01)。结论老年和女性原发性高血压患者血浆肾素活性水平较低。低肾素患者血压昼夜节律改变更明显,以非杓型血压多见。
|
关 键 词: | 高血压 肾素-血管紧张素系统 血压 膳食,限钠 昼夜节律 |
Relation of plasma renin activity level with blood pressure and natriuresis in essential hypertension patients |
| |
Affiliation: | JIANG Juan,SUN Ning-ling,WANG Hong-yi,et al (Cardiology Center,Peking University People’s Hospital,Beijing 100044,China) |
| |
Abstract: | Objective To study the relation of plasma renin activity level with blood pressure and natriuresis in essential hypertension patients.Methods Four hundred and seventy-nine essential hypertension patients were divided into low renin level group(n = 93),medium rennin level group (n = 291),and high rennin level group(n = 95) according to their renin activity level.Relation of plasma rennin activity level with 24 h ambulatory blood pressure and natriuresis was analyzed in 3 groups.Results The age was slightly younger while the plasma renin activity level was significantly higher in medium and high renin level groups than in low renin level group(P<0.05,P< 0.01).The proportion of aged subjects,females,and non-dipper blood pressure was significantly higher in low renin level group than in high renin level group(P<0.01).The 24 h plasma renin activity level was negatively related with the 24 h natriuresis and blood pressure(P<0.05,P< 0.01).Conclusion The plasma renin activity level is lower in aged subjects and females with essential hypertension.The change in circadian rhythm of blood pressure,especially non-dipper blood pressure,is more significant in patients with a low renin level. |
| |
Keywords: | hypertension renin-angiotensin system blood pressure diet,sodium-restricted circadian rhythm |
本文献已被 CNKI 万方数据 等数据库收录! |
|