原发性高血压患者血浆肾素活性水平与血压和尿钠的关系

目的分析原发性高血压患者血浆肾素活性水平与血压、尿钠排泄的关系。方法原发性高血压患者479例,根据血浆肾素活性水平的5分位排序,分为3组,低肾素组93例,中间肾素组291例,高肾素组95例。各组血浆肾素活性与24 h动态血压及24 h尿钠排泄情况进行相关性分析。结果与低肾素组比较,中间肾素组和高肾素组年龄明显偏低,血浆肾素活性明显增高,差异有统计学意义(P<0.05,P<0.01)。低肾素组老年人、女性、非杓型血压比例明显高于高肾素组,差异有统计学意义(P<0.01)。血浆肾素活性水平与24 h尿钠排泄、24 h血压呈负相关(P<0.05,P<0.01)。结论老年和女性原发性高血压患者血浆肾素活性水平较低。低肾素患者血压昼夜节律改变更明显,以非杓型血压多见。

Relation of plasma renin activity level with blood pressure and natriuresis in essential hypertension patients

Objective To study the relation of plasma renin activity level with blood pressure and natriuresis in essential hypertension patients.Methods Four hundred and seventy-nine essential hypertension patients were divided into low renin level group(n = 93),medium rennin level group (n = 291),and high rennin level group(n = 95) according to their renin activity level.Relation of plasma rennin activity level with 24 h ambulatory blood pressure and natriuresis was analyzed in 3 groups.Results The age was slightly younger while the plasma renin activity level was significantly higher in medium and high renin level groups than in low renin level group(P<0.05,P< 0.01).The proportion of aged subjects,females,and non-dipper blood pressure was significantly higher in low renin level group than in high renin level group(P<0.01).The 24 h plasma renin activity level was negatively related with the 24 h natriuresis and blood pressure(P<0.05,P< 0.01).Conclusion The plasma renin activity level is lower in aged subjects and females with essential hypertension.The change in circadian rhythm of blood pressure,especially non-dipper blood pressure,is more significant in patients with a low renin level.