| Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα |
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| 引用本文： | 刘秀平,熊长云,李春红,杨德光.Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα[J].华中科技大学学报(医学英德文版),2007,27(4):354-357. |
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| 作者姓名： | 刘秀平 熊长云 李春红 杨德光 |
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| 作者单位： | College of Life Science and Technology Huazhong Universty of Science and Technology，Molecular Targets Development Program，National Cancer Institute-Frederick National Institutes of Health Frederick，Affiliated Tumor Hospital，Harbin Medical University，College of Agriculture，Northeast Agricultural University，Wuhan 430074，China，MD 21702，USA，Harbin 150030，China，Harbin 150030，China |
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| 基金项目： | This project was supported by a grant from NIH foundation of USA. |
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| 摘 要： | Human interleukin-15(IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis,which is a potential therapeutic agent.The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis.TNFα was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course.Moreover,this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting.It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
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| 关 键 词： | 白细胞间介素-15 嗜中性粒细胞 细胞凋亡 细胞研究 |
| 收稿时间： | 1 February 2007 |
| 修稿时间： | 2007-02-01 |
Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα |
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| Liu Xiuping,Xiong Changyun,Li Chunhong,Yang Deguang.Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2007,27(4):354-357. |
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| Authors: | Liu Xiuping Xiong Changyun Li Chunhong Yang Deguang |
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| Institution: | 1.College of ldfe Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China; 2.Molecular Targets Development Program, National Cancer Institute-Frederick National Institutes of Health Frederick, AID 21702 USA ;3.Affiliated Tumor Hospital, Harbin Medical University, Harbin 150030, China; 4.College of Agriculture, Northeast Agricultural University, Harbin 150030, China |
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| Abstract: | Summary Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic
agent. The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFα was
shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect
by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting.
It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
LIU Xiuping, male, born in 1971, Ph.D.
This project was supported by a grant from NIH foundation of USA. |
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| Keywords: | neutrophil interleukin-15 TNFα apoptosis Bcl-Xl |
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